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首页> 外文期刊>Biomaterials >A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing
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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

机译：包含姜黄素的可生物降解水凝胶系统，其包裹在胶束中，可用于皮肤伤口愈合

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摘要

A biodegradable in situ gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent. Due to its high hydrophobicity, curcumin was encapsulated in polymeric micelles (Cur-M) with high drug loading and encapsulation efficiency. Cur-M loaded thermosensitive hydrogel (Cur-M-H) was prepared and applied as wound dressing to enhance the cutaneous wound healing. Cur-M-H was a free-flowing sol at ambient temperature and instantly converted into a non-flowing gel at body temperature. Invitro studies suggested that Cur-M-H exhibited well tissue adhesiveness and could release curcumin in an extended period. Furthermore, linear incision and full-thickness excision wound models were employed to evaluate the invivo wound healing activity of Cur-M-H. In incision model, Cur-M-H-treated group showed higher tensile strength and thicker epidermis. In excision model, Cur-M-H group exhibited enhancement of wound closure. Besides, in both models, Cur-M-H-treated groups showed higher collagen content, better granulation, higher wound maturity, dramatic decrease in superoxide dismutase, and slight increase in catalase. Histopathologic examination also implied that Cur-M-H could enhance cutaneous wound repair. In conclusion, biodegradable Cur-M-H composite might have great application for wound healing.
机译：制备了由载有姜黄素的胶束和热敏性水凝胶组成的可生物降解的原位凝胶形成控制药物递送系统，并将其用于皮肤伤口修复。姜黄素被认为是有效的抗氧化剂和消炎剂。由于其高疏水性，姜黄素被包裹在高分子胶束（Cur-M）中，具有很高的载药量和包裹效率。制备载有Cur-M的热敏水凝胶（Cur-M-H），并用作伤口敷料，以增强皮肤伤口的愈合。 Cur-M-H在环境温度下为自由流动的溶胶，在人体温度下立即转变为非流动的凝胶。体外研究表明，Cur-M-H表现出良好的组织粘附性，并可以长时间释放姜黄素。此外，采用线性切口和全层切除伤口模型来评估Cur-M-H的体内伤口愈合活性。在切口模型中，Cur-M-H处理组显示出较高的拉伸强度和较厚的表皮。在切除模型中，Cur-M-H组显示出伤口闭合的增强。此外，在两个模型中，Cur-M-H处理组均显示更高的胶原蛋白含量，更好的肉芽形成，更高的伤口成熟度，超氧化物歧化酶显着下降和过氧化氢酶略有增加。组织病理学检查还暗示，Cur-M-H可以增强皮肤伤口修复。总之，可生物降解的Cur-M-H复合材料可能在伤口愈合中具有重要的应用。

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