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首页> 外文期刊>Biomaterials >One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles
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One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles

机译：与人源化抗mPEG双特异性抗体的一步混合可增强mPEG化纳米颗粒的肿瘤积累和治疗功效

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摘要

Methoxy PEGylated nanoparticles (mPEG-NPs) are increasingly used for cancer imaging and therapy. Here we describe a general and simple approach to confer tumor tropism to any mPEG-NP. We demonstrate this approach with humanized bispecific antibodies (BsAbs) that can bind to both mPEG molecules on mPEG-NPs and to EGFR or HER2 molecules overexpressed on the surface of cancer cells. Simple mixing of BsAbs with mPEG-NPs can mediate preferential binding of diverse mPEG-NPs to cancer cells that overexpress EGFR or HER2 under physiological conditions and significantly increase cancer cell killing by liposomal doxorubicin to EGFR+ and HER2+ cancer cells. BsAbs modification also enhanced accumulation of fluorescence-labeled NPs and significantly increased the anticancer activity of drug-loaded NPs to antigen-positive human tumors in a mouse model. Anti-mPEG BsAbs offer a simple one-step method to confer tumor specificity to mPEG-NPs for enhanced tumor accumulation and improved therapeutic efficacy.
机译：甲氧基聚乙二醇化纳米颗粒（mPEG-NP）越来越多地用于癌症成像和治疗。在这里，我们描述了赋予所有mPEG-NP肿瘤趋向性的通用且简单的方法。我们用人源化双特异性抗体（BsAbs）证明了这种方法，该抗体可以与mPEG-NP上的mPEG分子以及在癌细胞表面过度表达的EGFR或HER2分子结合。 BsAb与mPEG-NP的简单混合可介导多种mPEG-NP与在生理条件下过表达EGFR或HER2的癌细胞的优先结合，并显着增加脂质体对阿霉素对EGFR +和HER2 +癌细胞的杀伤力。 BsAbs修饰还增强了荧光标记NP的积累，并显着提高了载药NP对小鼠模型中抗原阳性人类肿瘤的抗癌活性。抗mPEG BsAbs提供了一种简单的一步法即可赋予mPEG-NP肿瘤特异性，从而增强肿瘤蓄积和改善治疗效果。

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