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首页> 外文期刊>Biomaterials >Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging
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Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging

机译：含有磁性纳米颗粒，量子点和抗癌药物的可生物降解聚合物囊泡，用于药物递送和成像

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We have developed biodegradable polymeric vesicles as a nanocarrier system for multimodal bio-imaging and anticancer drug delivery. The poly(lactic-co-glycolic acid) (PLGA) vesicles were fabricated by encapsulating inorganic imaging agents of superparamagnetic iron oxide nanoparticles (SPION), manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs) and the anticancer drug busulfan into PLGA nanoparticles via an emulsion-evaporation method. T2*-weighted magnetic resonance imaging (MRI) of PLGA-SPION-Mn:ZnS phantoms exhibited enhanced negative contrast with r2* relaxivity of approximately 523s-1mM-1 Fe. Murine macrophage (J774A) cellular uptake of PLGA vesicles started fluorescence imaging at 2h and reached maximum intensity at 24h incubation. The drug delivery ability of PLGA vesicles was demonstrated invitro by release of busulfan. PLGA vesicle degradation was studied invitro, showing that approximately 32% was degraded into lactic and glycolic acid over a period of 5 weeks. The biodistribution of PLGA vesicles was investigated invivo by MRI in a rat model. Change of contrast in the liver could be visualized by MRI after 7min and maximal signal loss detected after 4h post-injection of PLGA vesicles. Histological studies showed that the presence of PLGA vesicles in organs was shifted from the lungs to the liver and spleen over time.
机译：我们已经开发了可生物降解的聚合物囊泡，作为用于多峰生物成像和抗癌药物递送的纳米载体系统。通过包裹超顺磁性氧化铁纳米粒子（SPION），锰掺杂的硫化锌（Mn：ZnS）量子点（QDs）和抗癌药物白消安制成无机成像剂来制造聚乳酸-乙醇酸（PLGA）囊泡。通过乳液蒸发法将其转化为PLGA纳米粒子。 PLGA-SPION-Mn：ZnS体模的T2 *加权磁共振成像（MRI）表现出增强的负对比度，r2 *弛豫度约为523s-1mM-1 Fe。 PLGA囊泡对小鼠巨噬细胞（J774A）的细胞摄取在2h开始荧光成像，并在24h孵育达到最大强度。 PLGA囊泡的释药能力通过释放白消安而得到体外证明。体外研究了PLGA囊泡的降解，显示在5周的时间内约32％被降解为乳酸和乙醇酸。在大鼠模型中通过MRI体内研究了PLGA囊泡的生物分布。注射PLGA囊泡7h后，可以通过MRI观察肝脏中对比度的变化，并在检测到最大信号丢失后观察到最大的信号丢失。组织学研究表明，随着时间的推移，器官中PLGA囊泡的存在已从肺转移到肝和脾。

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