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首页> 外文期刊>Biomaterials >Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer
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Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer

机译：全氟辛基溴化物聚吡咯纳米/微胶囊的工程设计，用于同时对比增强超声成像和光热疗法治疗癌症

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A versatile oil-in-water emulsion method has been explored for constructing water-dispersible polypyrrole (PPy) nano-/microcapsules with a soluble PPy complex as multifunctional photothermal agents for tumor ablation. In this work, both PPy nanocapsules (280.4±79.0nm) and microcapsules (1.31±0.45μm) with liquid perfluorooctylbromide (PFOB) core could be obtained by simply tuning the process energy for emulsion formation from ultrasonication to homogenization. Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. Thus, it is anticipated that fine-tuning of the other encapsulated drugs or functional materials in PPy capsules would foster avenues for the development of multifunctional platforms for cancer treatments.
机译：已经探索了一种通用的水包油乳液方法，该方法用于构建具有可溶性PPy复合物作为多功能消融剂的水分散性聚吡咯（PPy）纳米/微胶囊。在这项工作中，只需简单地调节从超声处理到均质化乳液形成的过程能量，即可获得具有液体全氟辛基溴化物（PFOB）核心的PPy纳米胶囊（280.4±79.0nm）和微胶囊（1.31±0.45μm）。由于封装的液体PFOB和PPy外壳的强近红外（NIR）吸收，所得PPy胶囊在超声成像引导的肿瘤细胞光热消融中显示出巨大的希望，而不会引起任何明显的副作用。因此，可以预料的是，PPy胶囊中其他封装药物或功能材料的微调将为开发用于癌症治疗的多功能平台开辟道路。

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