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首页> 外文期刊>Biomaterials >Water-dispersible magnetic carbon nanotubes as T2-weighted MRI contrast agents
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Water-dispersible magnetic carbon nanotubes as T2-weighted MRI contrast agents

机译：水分散性磁性碳纳米管作为T2加权MRI造影剂

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摘要

An efficient MRI T2-weighted contrast agent incorporating a potential liver targeting functionality was synthesized via the combination of superparamagnetic iron oxide (SPIO) nanoparticles with multiwalled carbon nanotubes (MWCNTs). Poly(diallyldimethylammonium chloride) (PDDA) was coated on the surface of acid treated MWCNTs via electrostatic interactions and SPIO nanoparticles modified with a potential targeting agent, lactose-glycine adduct (Lac-Gly), were subsequently immobilized on the surface of the PDDA-MWCNTs. A narrow magnetic hysteresis loop indicated that the product displayed superparamagnetism at room temperature which was further confirmed by ZFC (zero field cooling)/FC (field cooling) curves measured by SQUID. The multifunctional MWCNT-based magnetic nanocomposites showed low cytotoxicity invitro to HEK293 and Huh7 cell lines. Enhanced T2 relaxivities were observed for the hybrid material (186mm-1s-1) in comparison with the pure magnetic nanoparticles (92mm-1s-1) due to the capacity of the MWCNTs to "carry" more nanoparticles as clusters. More importantly, after administration of the composite material to an invivo liver cancer model in mice, a significant increase in tumor to liver contrast ratio (277%) was observed in T2 weighted magnetic resonance images.
机译：通过将超顺磁性氧化铁（SPIO）纳米粒子与多壁碳纳米管（MWCNT）结合，合成了一种有效的MRI T2加权造影剂，该造影剂具有潜在的肝脏靶向功能。聚（二烯丙基二甲基氯化铵）（PDDA）通过静电相互作用涂覆在酸处理的MWCNT的表面上，并用潜在的靶向剂乳糖-甘氨酸加合物（Lac-Gly）改性的SPIO纳米颗粒随后被固定在PDDA-的表面上多壁碳纳米管。狭窄的磁滞回线表明该产品在室温下显示超顺磁性，这进一步由SQUID测量的ZFC（零磁场冷却）/ FC（磁场冷却）曲线进一步证实。多功能基于MWCNT的磁性纳米复合材料在体外对HEK293和Huh7细胞系显示出低细胞毒性。与纯磁性纳米粒子（92mm-1s-1）相比，杂化材料（186mm-1s-1）的T2弛豫性得到了增强，这是因为MWCNT能够“携带”更多的纳米粒子簇。更重要的是，将复合材料施用于小鼠体内肝癌模型后，在T2加权磁共振图像中观察到肿瘤与肝脏的对比度显着提高（277％）。

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