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A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models

机译:通过斑马鱼模型系统评价纳米磷颗粒的体内毒性

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Lanthanide ion-doped nanophosphors are an emerging group of nanomaterials with excellent optical properties, and have been suggested as alternatives to quantum dots. In this letter, we determine the in-vitro and in-vivo toxicity of β-NaYF4:Ce,Tb nanophosphors using Capan-1 cells and embryonic zebrafish, respectively. In particular, we are the first to report on the in-vivo toxicity of β-phase nanophosphors and examine phenotypic developmental abnormalities (growth retardation, heart deformity, and bent tail), apoptotic cell death, and changes in heart function due to the nanophosphors. This study suggests the use of β-NaYF4:Ce,Tb nanophosphors as alternatives for QDs in a wide variety of biomedical imaging applications.
机译:镧系元素离子掺杂的纳米磷光体是一种新兴的具有优异光学性能的纳米材料,已被建议作为量子点的替代物。在这封信中,我们分别使用Capan-1细胞和胚胎斑马鱼确定了β-NaYF4:Ce,Tb纳米荧光粉的体外和体内毒性。特别是,我们是第一个报告β相纳米磷光体在体内毒性并检查表型发育异常(生长迟缓,心脏畸形和尾巴弯曲),凋亡性细胞死亡以及纳米磷光体引起的心功能变化的人。 。这项研究建议在多种生物医学成像应用中使用β-NaYF4:Ce,Tb纳米磷光体作为QD的替代品。

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