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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.
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Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.

机译:两种乙烯连接的双核二茂铁/钌有机金属混合物种的比较生物学评估。

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摘要

Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines.
机译:与具有苯乙烯基取代基或配体的结构相关的单核二茂铁或钌物种相比,对两种乙烯连接的双核混合二茂铁/钌配合物进行了生物学研究。结果表明,电子分布(但不是氧化还原电位),细胞摄取和(在较小程度上)抗雌激素作用是在肿瘤细胞系中观察到的抗增殖作用的关键因素。

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