Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

Meduna SP; Savall BM; Cai H; Edwards JP; Thurmond RL; McGovern PM

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Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

机译：三氨基嘧啶和吡啶作为组胺H（4）受体调节剂。

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Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H(4) receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.

机译：合成了两个系列的三氨基嘧啶和一系列的三氨基吡啶，并在竞争性结合和功能测定中评估了它们在H（4）受体上的活性的结构-活性关系。这三个杂芳族核中的小结构变化影响了这些化合物的功能活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共4页
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Meduna SP; Savall BM; Cai H; Edwards JP; Thurmond RL; McGovern PM;
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1. Triamino pyrimidines and pyridines as histamine H(4) receptor modulators. [J] . Meduna SP, Savall BM, Cai H, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：三氨基嘧啶和吡啶作为组胺H（4）受体调节剂。
2. The effect of pK(a) on pyrimidine/pyridine-derived histamine H-4 ligands [J] . Savall Brad M., Meduna Steven P., Venable Jennifer, Bioorganic and Medicinal Chemistry Letters . 2014,第23期

机译：pK（a）对嘧啶/吡啶衍生的组胺H-4配体的影响
3. Regional differential effects of the novel histamine H3 receptor antagonist 6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridine carboxamide hydrochloride (GSK189254) on histamine release in the central nervous system of freely moving rats. [J] . Giannoni P, Medhurst AD, Passani M The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2010,第1期

机译：新型组胺H3受体拮抗剂6-（（（3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl）oxy）-N-甲基-3-吡啶甲酰胺盐酸盐的区域差异作用（GSK189254）对自由运动大鼠中枢神经系统中组胺的释放。
4. Active H_1 -receptors protect against the harmful effects of H_2-receptors in a histamine induced brain edema model [C] . R. De Jongh, A. Smets, R. Nuydens, European Meeting on Glial Cells in Health and Disease . 2009

机译：活跃的H_1-refeptors防止H_2-受体在组胺诱导的脑水肿模型中的有害影响
5. Novel mechanisms of cardioprotection: Catecholamine release by natriuretic peptides: Characterization and prevention; activation of ALDH2 in mast cell mitochondria: Prevention of local angiotensin II formation; activation of histamine H3-receptors: Reduction of angiotensin AT1-receptor neuronal expression [D] . Chan, Noel Yan-ki 2012

机译：心脏保护的新机制：利钠肽释放儿茶酚胺：表征和预防；肥大细胞线粒体中ALDH2的激活：预防局部血管紧张素II的形成； H3受体的活化：降低血管紧张素AT1受体神经元表达
6. Synthesis and evaluation of an 18F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas [O] . Dustin Wayne Demoin, Masahiro Shindo, Hanwen Zhang, -1

机译：靶向胶质瘤中CXCR4受体的18F标记嘧啶-吡啶胺的合成与评价
7. Synthesis and evaluation of an 18 F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas [O] . Dustin Wayne Demoin, Masahiro Shindo, Hanwen Zhang, 2016

机译：18 F标记的嘧啶 - 吡啶胺用于靶向GLIMAS的CXCR4受体的合成与评价

Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

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