Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.

Chahrour O; Abdalla A; Lam F; Midgley C; Wang S

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Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.

机译：苯甲基苯乙烯基磺酰基衍生物作为有效的抗癌有丝分裂抑制剂的合成及生物学评估。

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We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

机译：我们在本文中报道了苄基苯乙烯砜，苄基苯乙烯磺酸和苄基磺酰基-N-苯基乙酰胺的衍生物的合成，生物学活性和结构活性关系。前导化合物7代表一类新的有丝分裂抑制剂，其显示出有效的抗增殖活性并选择性地诱导癌细胞凋亡，同时保留了未转化的肺成纤维细胞。

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《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共4页
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Chahrour O; Abdalla A; Lam F; Midgley C; Wang S;
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1. Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors. [J] . Chahrour O, Abdalla A, Lam F, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：苯甲基苯乙烯基磺酰基衍生物作为有效的抗癌有丝分裂抑制剂的合成及生物学评估。
2. Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. [J] . Qin H, Liu C, Zhang J, Bioorganic and Medicinal Chemistry Letters . 2010,第9期

机译：新型2-芳基烷硫基-4-氨基-6-苄基嘧啶作为有效的HIV-1非核苷逆转录酶抑制剂的合成及生物学评估。
3. Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. [J] . Qin H, Liu C, Zhang J, Bioorganic and Medicinal Chemistry Letters . 2010,第9期

机译：新型2-芳基烷硫基-4-氨基-6-苄基嘧啶作为有效的HIV-1非核苷逆转录酶抑制剂的合成及生物学评估。
4. Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent 2-benzyl-3, 4-dihydroisoquinolin-1(2H)-one and Its Derivatives [C] . Jian Lv, Lei Lv, Xiaomin Zhang, International conference on applied biotechnology . 2014

机译：新型抗肿瘤药2-苄基-3、4-二氢异喹啉-1（2H）-及其衍生物的设计，合成及生物学评价
5. Part A: Studies towards total synthesis of an anticancer and antifungal natural product, Pseudolaric acid B; Part B: Synthesis and biological evaluation of Berkeleyamide A and its derivatives [D] . Kulkarni, Swapnil J. 2011

机译：A部分：关于抗癌和抗真菌天然产物假烟酸B的全合成的研究； B部分：伯克利酰胺A及其衍生物的合成和生物学评价
6. Design of new disubstituted imidazo12-bpyridazine derivatives as selective Haspin inhibitors. Synthesis binding mode and anticancer biological evaluation [O] . Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, 2020

机译：新的二取代的咪唑（吡啶嗪衍生物为选择性HAPIN抑制剂的设计。合成结合模式和抗癌生物学评估
7. Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors [O] . Chahrour Osama, Abdalla Ashraf, Lam Frankie, 2011

机译：苄基苯乙烯基磺酰基衍生物作为有效的抗癌有丝分裂抑制剂的合成和生物学评价

Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.

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