Synthesis of a fluorescence resonance energy transfer-based probe containing a tricyclic nucleoside analog for single nucleotide polymorphism typing

Hayai Aya; Maeda Yusuke; Ueno Yoshihito

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Synthesis of a fluorescence resonance energy transfer-based probe containing a tricyclic nucleoside analog for single nucleotide polymorphism typing

机译：包含三环核苷类似物用于单核苷酸多态性分型的基于荧光共振能量转移的探针的合成

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Here, we report the synthesis of a fluorescence resonance energy transfer (FRET)-based probe for single nucleotide polymorphism (SNP) typing. The probe contains a fluorescent tricyclic base, 8-amino-3-(2,3-dihydroxypropyl) imidazo[40,50: 5,6] pyrido[2,3-d] pyrimidine, as a donor molecule and 7-diethy-laminocoumarin-3-carboxylic acid as an acceptor molecule. FRET was observed between the donor and acceptor molecules on the probe. The identity of the target bases on DNA and RNA strands could be determined using the probe. (C) 2016 Elsevier Ltd. All rights reserved.

机译：在这里，我们报告基于荧光共振能量转移（FRET）的探针的单核苷酸多态性（SNP）分型的合成。该探针包含一个荧光三环碱基，8-氨基-3-（2,3-二羟丙基）咪唑并[40,50：5,6]吡啶并[2,3-d]嘧啶作为供体分子，而7-二乙基-氨基香豆素-3-羧酸作为受体分子。在探针上的供体和受体分子之间观察到FRET。可以使用探针确定基于DNA和RNA链的目标碱基的身份。（C）2016 Elsevier Ltd.保留所有权利。

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《Bioorganic and Medicinal Chemistry Letters》 |2016年第15期|共4页
作者
Hayai Aya; Maeda Yusuke; Ueno Yoshihito;
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正文语种 eng
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关键词
SNPs; FRET; Probe; Fluorescence; DNA; RNA;

机译：SNPs;FRET;探针;荧光;DNA;RNA;

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1. Synthesis of a fluorescence resonance energy transfer-based probe containing a tricyclic nucleoside analog for single nucleotide polymorphism typing [J] . Hayai Aya, Maeda Yusuke, Ueno Yoshihito Bioorganic and Medicinal Chemistry Letters . 2016,第15期

机译：包含三环核苷类似物用于单核苷酸多态性分型的基于荧光共振能量转移的探针的合成
2. Evaluation of Molecular-Beacon, TaqMan, and Fluorescence Resonance Energy Transfer Probes for Detection of Antibiotic Resistance-Conferring Single Nucleotide Polymorphisms in Mixed Mycobacterium tuberculosis DNA Extracts [J] . Hasan Yesilkaya, Francesca Meacci, Stefan Niemann, Journal of Clinical Microbiology . 2006,第10期

机译：评价分子信标，TaqMan和荧光共振能量转移探针以检测混合结核分枝杆菌DNA提取物中赋予抗生素抗性的单核苷酸多态性
3. Fluorescence detection of single nucleotide polymorphisms using nucleic acid probe containing tricyclic base-linked acyclonucleoside [J] . HattoriM., OhkiT., YanaseE., Bioorganic and Medicinal Chemistry Letters . 2012,第1期

机译：使用含有三环基碱基环核苷核苷的核酸探针的单核苷酸多态性的荧光检测
4. Microarray-based approach for high-throughput genotyping of single nucleotide polymorphisms with Layer-by-Layer dual-color fluorescence hybridization [C] . . 2005

机译：基于微阵列的单核苷酸多态性高通量基因分型方法与逐层双色荧光杂交
5. The Effect of Single Nucleotide Polymorphisms in Apolipoprotein(a) KIV Types 6-9 on Lipoprotein(a) Particle Assembly and Apolipoprotein(a) Secretion In Vitro [D] . Sayegh, Sera. 2018

机译：载脂蛋白（a）KIV 6-9型单核苷酸多态性对脂蛋白（a）颗粒装配和载脂蛋白（a）体外分泌的影响
6. Evaluation of Molecular-Beacon TaqMan and Fluorescence Resonance Energy Transfer Probes for Detection of Antibiotic Resistance-Conferring Single Nucleotide Polymorphisms in Mixed Mycobacterium tuberculosis DNA Extracts [O] . Hasan Yesilkaya, Francesca Meacci, Stefan Niemann, 2006

机译：评价分子信标TaqMan和荧光共振能量转移探针以检测混合结核分枝杆菌DNA提取物中赋予抗生素抗性的单核苷酸多态性
7. Evaluation of Molecular-Beacon, TaqMan, and Fluorescence Resonance Energy Transfer Probes for Detection of Antibiotic Resistance-Conferring Single Nucleotide Polymorphisms in Mixed Mycobacterium tuberculosis DNA Extracts [O] . Yesilkaya, Hasan, Meacci, Francesca, Niemann, Stefan, 2006

机译：评价分子信标，TaqMan和荧光共振能量转移探针以检测混合结核分枝杆菌DNA提取物中赋予抗生素抗性的单核苷酸多态性
8. Synthesis of Purine Nucleoside and Nucleotide Analogs as Antiparasitic Agents [R] . Neenan, J. P. 1979

机译：嘌呤核苷和核苷酸类似物作为抗寄生虫剂的合成

Synthesis of a fluorescence resonance energy transfer-based probe containing a tricyclic nucleoside analog for single nucleotide polymorphism typing

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