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首页> 外文期刊>Biochemical and Biophysical Research Communications >Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens
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Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens

机译：大颗粒过敏原可以引起肥大细胞介导的过敏反应而不会像小的可溶性过敏原一样有效地退出血管

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摘要

Anaphylaxis is a rapid-onset, life-threatening allergic reaction in that IgE, mast cells and histamine are commonly involved. It can be experimentally induced in IgE-sensitized animals by intravenous injection of corresponding allergens, and the sign of anaphylactic reaction can be detected within minutes after allergen challenge. However, it remains puzzling why the anaphylactic reaction can be initiated in vivo so quickly, considering that allergens are delivered into the blood circulation while mast cells reside within peripheral tissues but not in the blood circulation. To address this issue, we compared two different forms of the same allergen, small soluble and large particulate ones, in their ability to induce anaphylaxis in IgE-sensitized mice. In contrast to our expectation, particulate allergens could induce anaphylaxis as quickly and efficiently as did soluble allergens, even though they remained inside of blood vessels. In vivo imaging analysis suggested the direct interaction of intravascular particulate allergens and perivascular mast cells across the capillary wall. Taken together with previous report that perivascular mast cells can capture IgE in the blood circulation by extending cell processes across the vessel wall, our findings imply that blood-circulating allergens, regardless of their size, can stimulate mast cells without exit from blood vessels, by means of cross-linking IgE on mast cell processes inserted into the vessel lumen, and hence initiate anaphylactic reaction so quickly. (C) 2015 Elsevier Inc. All rights reserved.
机译：过敏反应是一种快速发作的，威胁生命的过敏反应，通常涉及IgE，肥大细胞和组胺。可以通过静脉注射相应的过敏原在IgE致敏的动物中通过实验诱导，并且在过敏原攻击后的几分钟内即可检测到过敏反应迹象。但是，考虑到变应原被递送到血液循环中而肥大细胞驻留在外周组织中而不是血液循环中，为什​​么过敏反应能够如此迅速地在体内引发，仍然令人费解。为了解决这个问题，我们比较了两种相同形式的过敏原的不同形式：小可溶性和大颗粒，它们在IgE致敏小鼠中引起过敏反应的能力。与我们的预期相反，颗粒状变应原可以像可溶性变应原一样快速有效地诱发过敏反应，即使它们仍留在血管内部。体内成像分析表明，血管内颗粒过敏原与毛细血管壁上血管周围肥大细胞的直接相互作用。结合先前的报道，血管周肥大细胞可通过跨血管壁扩展细胞过程而捕获血液循环中的IgE，我们的发现表明，不论大小，血液循环变应原均可以刺激肥大细胞而不会从血管中排出。 IgE在插入到血管腔中的肥大细胞过程中的交联手段，因此可以如此迅速地引发过敏反应。 （C）2015 Elsevier Inc.保留所有权利。

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