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首页> 外文期刊>Brain research >Dopamine and cognitive control: the influence of spontaneous eyeblink rate, DRD4 exon III polymorphism and gender on flexibility in set-shifting.
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Dopamine and cognitive control: the influence of spontaneous eyeblink rate, DRD4 exon III polymorphism and gender on flexibility in set-shifting.

机译:多巴胺和认知控制:自发眨眼率,DRD4外显子III多态性和性别对移位灵活性的影响。

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摘要

Converging evidence suggests a modulatory role of dopamine in cognitive control. We investigated the influence of two correlates of dopaminergic activity, the spontaneous eyeblink rate and the DRD4 exon III polymorphism, and the potential impact of gender on flexibility in an attentional set-shifting paradigm. The objective of the study was to confirm previous findings of an association between high eyeblink rates and increased cognitive flexibility. These findings were replicated in 87 healthy volunteers this time using a continuous variable for eyeblink rates instead of a dichotomized variable. The interaction between eyeblink rate and DRD4 found in the previous study was lower and failed significance. Analysis of the collapsed sample of n=150 revealed a main effect of gender and an interaction of gender and eyeblink rate on cognitive control. The complete prediction model explained 26% of the total variance. These data suggest that (1) the eyeblink rate is a reliable predictor of dopamine-mediated flexibility of cognitive control and (2) it is useful to include gender as predictor in future studies of dopaminergic modulation of cognitive control.
机译:越来越多的证据表明,多巴胺在认知控制中起调节作用。我们调查了多巴胺能活动的两个相关因素的影响,即自发眨眼率和DRD4外显子III多态性,以及性别对注意力转移的潜在影响。这项研究的目的是要确认以前的高眨眼率与认知灵活性增加之间的关联的发现。这次使用连续变量而不是二分变量在87名健康志愿者中复制了这些发现。先前研究中发现的眨眼率与DRD4之间的相互作用较低,且意义不大。对n = 150的倒塌样本进行的分析显示,性别主要影响以及性别和眨眼频率对认知控制的相互作用。完整的预测模型解释了总方差的26%。这些数据表明(1)眨眼率是多巴胺介导的认知控制灵活性的可靠预测指标,(2)在将来对认知控制的多巴胺能调节进行研究时,将性别作为预测指标是有用的。

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