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首页> 外文期刊>Brain research >CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.
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CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.

机译：路易氏体和阿尔茨海默氏病痴呆患者的CSFα-突触核蛋白水平。

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摘要

Dementia with Lewy bodies (DLB) is characterized by widespread depositions of alpha-synuclein, which are described as Lewy bodies. Recently, it was shown that neuronal cells in culture constitutively release alpha-synuclein into the culture medium and that alpha-synuclein is normally present in human cerebrospinal fluid (CSF). The aim of the present study was to evaluate the diagnostic value of CSF alpha-synuclein levels in discriminating DLB from Alzheimer's disease (AD). Alpha-synuclein was measured in CSF from 16 patients with DLB and 21 patients with AD. Iodine-123 metaiodobenzylguanidine cardiac scintigraphy was also performed to assess Lewy body pathology. CSF alpha-synuclein levels did not differ significantly between DLB and AD patients. However, the duration of illness was associated with lower alpha-synuclein levels (p<0.05) in DLB, while no such association was found in AD. The present data show CSF alpha-synuclein levels are not sensitive diagnostic markers to discriminate DLB from AD. However, the lower alpha-synuclein levels in DLB patients with longer duration suggest a reduction in CSF alpha-synuclein in association with increased severity of alpha-synucleinopathy in the brain.
机译：路易体痴呆症（DLB）的特征是广泛分布的α-突触核蛋白沉积，被称为路易体。最近，显示了培养物中的神经元细胞将α-突触核蛋白组成性地释放到培养基中，并且α-突触核蛋白通常存在于人脑脊髓液（CSF）中。本研究的目的是评估CSFα-突触核蛋白水平在区分DLB和阿尔茨海默氏病（AD）中的诊断价值。在16例DLB患者和21例AD患者的脑脊液中检测到α-突触核蛋白。还进行了碘123碘碘苄基胍心脏闪烁显像以评估路易体病理。 DLB和AD患者之间的CSFα-突触核蛋白水平没有显着差异。然而，疾病的持续时间与DLB中较低的α-突触核蛋白水平相关（p <0.05），而在AD中未发现这种相关性。当前数据显示，CSFα-突触核蛋白水平不是区分DLB和AD的敏感诊断指标。然而，持续时间较长的DLB患者中较低的α-突触核蛋白水平提示CSFα-突触核蛋白减少，同时脑内α-突触核蛋白病的严重程度增加。

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