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首页> 外文期刊>Brain research >Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats.
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Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats.

机译：围产期窒息对新生大鼠神经行为和视网膜发育的影响。

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Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal asphyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.
机译：分娩期间的围产期窒息会产生长期的缺陷，这是新生儿和儿科护理中的主要问题。已经描述了围生期窒息大鼠的几种形态，生化和行为变化。本研究的目的是评估围产期窒息如何影响新生大鼠复杂的早期神经行为发育和视网膜结构。窒息15分钟后，通过剖腹剖宫术切除幼崽，即可在即将分娩的母亲体内诱发窒息。在头3周内每天进行身体和神经行为发育测试，并在出生后3-5周进行运动协调测试。测试程序完成后，将视网膜摘除以进行组织学分析。我们发现，尽管窒息幼仔的追赶速度很快，但几乎所有检查到的反射都延迟了1-4天：负地轴，感觉反射，直立反射，前肢和后肢抓握和放置，步态和步态的发展。听觉惊吓反射。在窒息幼崽的最初几周内，进行负轴测，表面矫正和步态反射的时间明显更长。在电机协调测试中，在网格行走和踩踏测试以及行走启动测试中观察到了明显较弱的性能。视网膜结构在感光细胞和双极细胞体层中显示出严重的变性。总之，我们的研究提供了围产期窒息后反射和运动发育的详细描述，表明窒息导致神经行为发育显着延迟和严重的视网膜变性。

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