...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >The stress-coping (mis)match hypothesis for nature×nurture interactions.
【24h】

The stress-coping (mis)match hypothesis for nature×nurture interactions.

机译：自然×养分相互作用的应激应对（错配）假设。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is high consensus that stress-related disorders like depression are shaped by nature×nurture interactions. However, the complexity appears larger than envisaged and nature×nurture research is progressing too slowly. An important reason is that mainstream research is focussing on the idea that a combination of genotypic stress-sensitivity and stress exposure inevitably leads to maladaptive stress-coping responses, and thereby stress-related disorders. However, stress-coping responses can also be adaptive and adhere to the expected norm. Here I elaborate the 'environment' mismatch hypothesis proposed by Mathias Schmidt (Psychoneuroendocrinology, 36, 330-338, 2011) to the stress-coping (mis)match (SCM) hypothesis postulating that stress-coping responses-as programmed by nature×age-dependent nurture interactions-are adaptive when they match current stress conditions, but maladaptive when they mismatch current stress conditions. For instance, acquisition of an active stress-coping response during nurture may lead to the programmed release of active coping responses in current life. This is adaptive when current stress is escapable, but maladaptive when current stress is inescapable, leading to agitation. A model par example for nature×nurture interactions is the serotonin transporter promoter polymorphism, which will be discussed in the framework of the SCM hypothesis. The potential role of the prefrontal-amygdala circuit and the therapeutic implications of the SCM hypothesis will also be discussed.
机译：人们普遍认为，与压力相关的疾病（如抑郁症）是由自然×养分相互作用所形成的。但是，复杂性似乎比预期的要大，自然与养育研究进展太慢。一个重要的原因是，主流研究集中在基因型应激敏感性和应激暴露相结合不可避免地导致适应不良的应激应对反应，进而导致与应激相关的疾病这一观念上。但是，压力应对响应也可以是自适应的，并且符合预期的规范。在这里，我详细阐述了Mathias Schmidt（Psychoneuroendocrinology，36，330-338，2011）提出的“环境应对不匹配”假说，该假说与“应对不当”（SCM）假说假设是根据自然×年龄编程的依赖的养分相互作用-在与当前压力条件匹配时是适应性的，但在与当前压力条件不匹配时则适应不良。例如，在养育过程中获得主动的压力应对响应可能导致当前生活中主动应对响应的编程释放。当可以避免当前压力时这是适应性的，但是当无法避免当前压力时会导致适应不良。 5-羟色胺转运蛋白启动子多态性是自然与营养相互作用的模型实例，将在SCM假设的框架内进行讨论。前额杏仁核回路的潜在作用以及SCM假设的治疗意义也将进行讨论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号