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Minocycline-induced attenuation of iron overload and brain injury after experimental germinal matrix hemorrhage

机译：实验性生发性基质出血后米诺环素诱导的铁超载衰减和脑损伤

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Germinal matrix hemorrhage (GMH) is the most important adverse neurologic event during the newborn period. Evidence has shown that neonates with GMH and hydrocephalus have more severe damage compared to those with GMH alone. Our preliminary study demonstrated the role of iron in hydrocephalus and brain damage in adult rats following intraventricular hemorrhage. Therefore, the aim of the current study was to investigate iron accumulation and iron-handling proteins in a rat model of GMH and whether minocycline reduces iron overload after GMH and iron-induced brain injury in vivo. This study was divided into two parts. In the first part, rats received either a needle insertion or an intracerebral injection of 0.3 U of clostridial collagenase VII-S. Brain iron and brain iron handling proteins (heme oxygenase-1 and ferritin) were measured. In the second part, rats with a GMH were treated with minocycline or vehicle. Brain edema, brain cell death, hydrocephalus, iron-handling proteins and long-term motor function were examined. The result showed iron accumulation and upregulation of iron-handling proteins after GMH. Minocycline treatment significantly reduced GMH-induced brain edema, hydrocephalus and brain damage. Minocycline also suppressed upregulation of ferritin after GMH. In conclusion, the current study found that iron plays a role in brain injury following GMH and that minocycline reduces iron overload after GMH and iron-induced brain injury. (C) 2014 Published by Elsevier B.V.
机译：发芽基质出血（GMH）是新生儿期最重要的不良神经系统事件。有证据表明，与单独使用GMH的婴儿相比，患有GMH和脑积水的新生儿的伤害更为严重。我们的初步研究证明了铁在脑室内出血后成年大鼠脑积水和脑损伤中的作用。因此，本研究的目的是研究GMH大鼠模型中的铁蓄积和铁处理蛋白，以及米诺环素是否可减少GMH和体内铁诱导的脑损伤后的铁超负荷。本研究分为两个部分。在第一部分中，大鼠接受了0.3 U的梭菌胶原酶VII-S的针头插入或脑内注射。测量了脑铁和脑铁处理蛋白（血红素加氧酶-1和铁蛋白）。在第二部分中，用美满霉素或赋形剂治疗患有GMH的大鼠。检查脑水肿，脑细胞死亡，脑积水，铁处理蛋白和长期运动功能。结果显示，GMH后铁积累和铁处理蛋白上调。米诺环素治疗可显着减少GMH引起的脑水肿，脑积水和脑损伤。米诺环素还抑制了GMH后铁蛋白的上调。总而言之，当前的研究发现，铁在GMH后脑损伤中起作用，而米诺环素可减少GMH和铁引起的脑损伤后铁超负荷。 （C）2014由Elsevier B.V.发布

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