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首页> 外文期刊>Brain research >Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1)
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Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1)

机译：衰老加速小鼠倾向1（SAMP1）的运动功能受损

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Senescence-accelerated mouse prone (SAMP) strains of mice show early onset of senescence, whereas senescence-accelerated mouse resistant (SAMR) strains are resistant to early senescence and serve as controls. Although SAMP6 and SAMP8 are established models of central nervous system alterations, it is unclear whether SAMP1/Sku (SAMP1) is characterized by brain alterations and dysfunction related to behavioral functioning. In the present study, behavioral tests (i.e.; locomotor activity, Y-maze, rotating rod, hind-limb extension, and traction), histochemistry, and Western blot analyses were employed to study this mouse model using 2- and 4-month-old SAMP1 and age-matched control SAMR1. Although 2-month-old SAMP1 and SAMR1 showed similar activity, 4-month-old SAMP1 exhibited less activity than age-matched SAMR1 in locomotor activity and Y-maze tests. In rotating rod test, 2- and 4-month-old SAMP1 showed motor-coordination dysfunction. An abnormal extension reflex in the hind-limb test was observed in 2- and 4-month-old SAMP1. There were no significant differences between SAMP1 and SAMR1 with respect to grip strength in the traction test or alternation behavior in the Y-maze test. Histochemistry and Western blot analyses exhibited that cerebellar Purkinje cells in 4-month-old SAMP1 mice persistently expressed tyrosine hydroxylase. These results suggest that SAMP1 is a useful model for examining mechanisms underlying motor dysfunction.
机译：小鼠的衰老加速小鼠易感性（SAMP）菌株显示出衰老的早期发作，而衰老加速小鼠抗性（SAMR）菌株对早期衰老具有抗性并用作对照。虽然SAMP6和SAMP8是中枢神经系统改变的模型，但尚不清楚SAMP1 / Sku（SAMP1）是否以大脑改变和与行为功能有关的功能障碍为特征。在本研究中，行为测试（即运动活动，Y型迷宫，旋转杆，后肢伸展和牵引），组织化学和蛋白质印迹分析被用于研究使用2个月和4个月的小鼠模型旧的SAMP1和年龄匹配的对照SAMR1。尽管两个月大的SAMP1和SAMR1表现出相似的活性，但是在运动活动和Y迷宫测试中，四个月大的SAMP1却比年龄匹配的SAMR1表现出更少的活性。在旋转棒试验中，2个月和4个月大的SAMP1表现出运动协调功能障碍。在2个月和4个月大的SAMP1中，后肢测试中观察到了异常的延伸反射。就牵引力测试中的握力或Y迷宫测试中的交替行为而言，SAMP1和SAMR1之间没有显着差异。组织化学和蛋白质印迹分析显示，在4个月大的SAMP1小鼠中，小脑Purkinje细胞持续表达酪氨酸羟化酶。这些结果表明，SAMP1是检查运动功能障碍潜在机制的有用模型。

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