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首页> 外文期刊>Brain research >Fish oil modulates glycogen synthase kinase-3 signaling pathway in diabetes-induced hippocampal neurons apoptosis
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Fish oil modulates glycogen synthase kinase-3 signaling pathway in diabetes-induced hippocampal neurons apoptosis

机译：鱼油调节糖尿病性海马神经元凋亡中糖原合酶激酶3信号通路

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摘要

Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. Dietary fatty acids, especially polyunsaturated fatty acids, have been shown to enhance learning and memory and prevent memory deficits in various experimental conditions. The present study investigated the effects of fish oil supplementation on the neuron apoptosis in the hippocampus of streptozotocin (STZ)-induced diabetes rats, further explored the effect of fish oil on the phosphorylation of protein kinase B and glycogen synthase kinase-3 beta. The effects of diabetes and fish oil treatment on the spatial learning and memory were also evaluated using the Morris Water Maze. STZ-induced diabetes impaired spatial learning and memory of rats, which was associated with the apoptosis of hippocampal neurons and oxidative stress. Fish oil administration ameliorated cognitive deficit, reduced oxidative stress, increased AKT phosphorylation, decreased GSK-3(3 phosphorylation, and decreased pro-apoptotic molecules expression, which protected the hippocampal neurons from apoptosis in diabetic rats. These results suggested a potential role for fish oil as an adjuvant therapy for the prevention and treatment of diabetic complications.
机译：先前的研究表明，糖尿病会诱发学习和记忆障碍。然而，人们对由糖尿病引起的记忆障碍的机制了解甚少。膳食脂肪酸，尤其是多不饱和脂肪酸，已显示出可以在各种实验条件下增强学习和记忆力并防止记忆力不足。本研究调查了鱼油补充对链脲佐菌素（STZ）诱导的糖尿病大鼠海马神经元凋亡的影响，并进一步探讨了鱼油对蛋白激酶B和糖原合酶激酶3β磷酸化的影响。还使用莫里斯水迷宫评估了糖尿病和鱼油治疗对空间学习和记忆的影响。 STZ诱导的糖尿病会损害大鼠的空间学习和记忆能力，这与海马神经元的凋亡和氧化应激有关。鱼油的施用改善了认知缺陷，减轻了氧化应激，增加了AKT磷酸化，降低了GSK-3（3磷酸化，并降低了促凋亡分子的表达，从而保护了海马神经元免于糖尿病大鼠的凋亡，这些结果表明了鱼的潜在作用。油作为预防和治疗糖尿病并发症的辅助疗法。

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