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首页> 外文期刊>Brain research >GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: Implications for REM sleep control
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GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: Implications for REM sleep control

机译：GABA A受体位于大鼠脑桥核内胆碱能末端：对REM睡眠控制的意义

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摘要

The oral pontine reticular formation (PnO) of rat is one region identified in the brainstem as a rapid eye movement (REM) sleep induction zone. Microinjection of GABAA receptor antagonists into PnO induces a long lasting increase in REM sleep, which is similar to that produced by cholinergic agonists. We previously showed that this REM sleep-induction can be completely blocked by a muscarinic antagonist, indicating that the REM sleep-inducing effect of GABAA receptor antagonism is dependent upon the local cholinergic system. Consistent with these findings, it has been reported that GABAA receptor antagonists microdialyzed into PnO resulted in increased levels of acetylcholine. We hypothesize that GABAA receptors located on cholinergic boutons in the PnO are responsible for the REM sleep induction by GABAA receptor antagonists through blocking GABA inhibition of acetylcholine release. Cholinergic, varicose axon fibers were studied in the PnO by immunofluorescence and confocal, laser scanning microscopy. Immunoreactive cholinergic boutons were found to be colocalized with GABAA receptor subunit protein γ2. This finding implicates a specific subtype and location of GABAA receptors in PnO of rat in the control of REM sleep.
机译：大鼠的口腔桥状网状结构（PnO）是在脑干中识别为快速眼动（REM）睡眠诱导区的一个区域。将GABAA受体拮抗剂微注射到PnO中会引起REM睡眠的长期持续增加，这与胆碱能激动剂产生的结果相似。我们以前表明，这种REM睡眠诱导作用可以被毒蕈碱拮抗剂完全阻断，这表明GABAA受体拮抗作用的REM睡眠诱导作用取决于局部胆碱能系统。与这些发现一致，据报道，GABAA受体拮抗剂微渗入PnO导致乙酰胆碱水平升高。我们假设位于PnO的胆碱能胸腺中的GABAA受体通过阻断GABA对乙酰胆碱释放的抑制作用，负责GABAA受体拮抗剂诱导的REM睡眠。通过免疫荧光和共聚焦激光扫描显微镜研究了PnO中胆碱能曲张的轴突纤维。发现免疫反应性胆碱能弹药与GABAA受体亚基蛋白γ2共定位。这一发现暗示了大鼠的PnO中GABA A受体的特定亚型和位置在REM睡眠的控制中。

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