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首页> 外文期刊>Brain research >Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats
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Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats

机译：在青春期大鼠情境恐惧调节的变异过程中，前额叶皮层，海马和杏仁核中的Egr-1 mRNA表达模式

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We report activation of the immediate-early gene Egr-l in the lateral amygdala (LA), hippocampus (CA1), and medial prefrontal cortex (mPFC) 30-min following the training phase in the context pre-exposure facilitation effect (CPFE) and standard context fear, conditioning (180 s context exposure→shock). On day one of the CPFE paradigm, postnatal day (PD) 31 rats (+1) were pre-exposed to Context A (Pre) or Context B (Alt-Pre) for 5 min followed by five additional 1-min exposures. A day later, Pre and Alt-Pre rats received a 2-s, 1.5 mA footshock immediately upon placement in Context A. Animals included in in situ hybridization were then sacrificed 30 (±3) min later. On day three, the behaviorally-tested Pre rats showed significantly more fear-conditioned freezing in Context A than Alt-Pre rats. Standard context fear conditioning groups showed much greater freezing than the Pre group, as well as no shock and immediate-shock controls/Thirty minutes after immediate shock training, Pre rats showed increased Egr-l mRNA in the prelimbic mPFC relative to Alt-Pre rats. Standard context conditioning selectively increased Egr-l in CA1. In the LA and mPFC, Egr-l increased to a similar extent in no shock, immediate shock, and standard context conditioning relative to homecage controls. The present study demonstrates that Egr-l mRNA expression has a complex relationship to fear learning in different brain regions and variants of context conditioning.
机译：我们报告了在暴露前促进促进作用（CPFE）的训练阶段后30分钟，外侧杏仁核（LA），海马（CA1）和内侧前额叶皮层（mPFC）中的立即早期基因Egr-1的激活和标准的上下文恐惧，调节（180 s上下文暴露→电击）。在CPFE范例的第一天，将产后一天（PD）的31只大鼠（+1）预先暴露于Context A（Pre）或Context B（Alt-Pre）5分钟，然后再暴露5次1分钟。一天后，将Pre和Alt-Pre大鼠置于Context A中后立即接受2 s，1.5 mA的休克。原位杂交的动物随后30（±3）分钟处死。在第三天，经过行为测试的Pre大鼠在情境A中表现出比Alt-Pre大鼠明显更多的恐惧条件冻结。标准情境恐惧条件调节组的冰冻程度比Pre组高得多，并且没有电击和立即电击控制/立即电击训练后30分钟，Pre大鼠显示相对于Alt-Pre大鼠，prelimbic mPFC中Egr-1 mRNA的升高。标准上下文条件有选择地增加了CA1中的Egr-1。在LA和mPFC中，相对于笼养控制，Egr-1在无电击，立即电击和标准环境调节的情况下增加了类似的程度。本研究表明，Egr-1 mRNA表达与在不同大脑区域和情境条件变体中的恐惧学习有着复杂的关系。

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