The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

Smith Alexander C. W.; Scofield Michael D.; Kalivas Peter W.

首页> 外文期刊>Brain research >The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

【24h】

The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

机译：四方突触：细胞外基质重塑有助于皮质成瘾药物潜在的成瘾性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Synaptic plasticity has long been known to involve three key elements of neuropil, the presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular matrix in synaptic plasticity as a necessary component forming the tetrapartite synapse. We describe the role of matrix metalloproteinases as enzymes sculpting extracellular proteins and thereby creating an extracellular signaling domain required for synaptic plasticity. Specifically we focus on the role of the tetrapartite synapse in mediating the effects of addictive drugs at cortico-striatal synapses, and conclude that the extracellular signaling domain and its regulation by matrix metalloproteinases is critical for developing and expressing drug seeking behaviors.

机译：长期以来，突触可塑性涉及神经纤维的三个关键要素，即突触前，突触后和邻近的神经胶质。在这里，我们审查细胞外基质在突触可塑性中作为形成四部分突触的必要成分的作用。我们描述了基质金属蛋白酶作为雕刻细胞外蛋白的酶的作用，从而创建了突触可塑性所需的细胞外信号结构域。具体来说，我们专注于四方突触在介导成瘾药物对皮质-纹状体突触的影响中的作用，并得出结论，胞外信号传导域及其受基质金属蛋白酶的调节对于发展和表达寻药行为至关重要。

著录项

来源
《Brain research》 |2015年第1期|共11页
作者
Smith Alexander C. W.; Scofield Michael D.; Kalivas Peter W.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
Extracellular matrix; Addiction; Nucleus accumbens; Matrix metalloproteinase; Integrin;

机译：细胞外基质;成瘾;伏隔核;基质金属蛋白酶;整联蛋白;

相似文献

外文文献
中文文献
专利

1. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [J] . Smith Alexander C. W., Scofield Michael D., Kalivas Peter W. Brain research . 2015,第Pta1期

机译：四方突触：细胞外基质重塑有助于皮质成瘾药物潜在的成瘾性
2. Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction [J] . Daniela Neuhofer, Peter Kalivas Neurobiology of learning and memory . 2018,第期

机译：上瘾的四氨酸突触的血管塑性：药物诱导适应和潜在治疗靶标的常见分母
3. Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells [J] . Ernesto Cortes, Benjamin K. Robinson, Alistair J. Rice, Biology Open . 2016,第6期

机译：胰腺星状细胞对3D细胞外基质重塑的定量分析胰腺星状细胞对3D细胞外基质重塑的定量分析
4. A biclustering approach to analyze drug effects on extracellular matrix remodeling post-myocardial infarction [C] . Ghasemi Omid, Nguyen Nguyen, Ramirez Trevi A, 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops. . 2012

机译：分析药物对心肌梗死后细胞外基质重塑的双聚类分析方法
5. Extracellular matrix remodeling: Potential mechanisms by which aldosterone blockade improves ventricular remodeling and function post myocardial infarction. [D] . Le, Jenny Wenyi. 2003

机译：细胞外基质重塑：醛固酮阻滞改善心肌梗死后心室重塑和功能的潜在机制。
6. The tetrapartite synapse: extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [O] . Alexander C.W. Smith, Michael D. Scofield, Peter W. Kalivas -1

机译：四方突触：细胞外基质重塑有助于潜在的成瘾性皮质激素可塑性。
7. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [O] . Alexander C.W. Smith, Michael D. Scofield, Peter W. Kalivas 2015

机译：Tetrapartite Synapse：细胞外基质重塑有助于皮质切割塑性潜在的药物成瘾

The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

摘要

著录项

相似文献

相关主题

期刊订阅