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首页> 外文期刊>Chemistry: A European journal >Graphene oxide noncovalent photosensitizer and its anticancer activity in vitro
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Graphene oxide noncovalent photosensitizer and its anticancer activity in vitro

机译：氧化石墨烯非共价光敏剂及其体外抗癌活性

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Graphene oxide (GO) was investigated as a potential drug-delivery system due to its special properties and biocompatibility. Thus far, little has been done to use GO as a photosensitive drug-delivery system and to explore its anticancer activity in vitro in photodynamic therapy applications. Here, a novel GO-hypocrellin A (GO-HA) hybrid was prepared by a simple noncovalent method and its photodynamic activity was studied for the first time. The results showed that an efficient loading amount of HA on GO was as high as 1.0 mg mg ~(-1) and the stability of the hybrid was superior to that of the free hypocrellin A in aqueous solution. Furthermore, GO-HA can be excited by irradiation with light of appropriate wavelength to generate singlet oxygen, and in vitro experiments illustrated that GO-HA was efficiently taken up by tumor cells, and that light irradiation of such impregnated cells resulted in significant cell death. Thus, these properties of GO-HA could possibly make it especially promising for use in clinical photodynamic therapy.
机译：氧化石墨烯（GO）由于其特殊的性能和生物相容性而被研究为潜在的药物递送系统。迄今为止，几乎没有做过将GO用作光敏药物递送系统并在光动力疗法应用中探索其体外抗癌活性的工作。在这里，通过简单的非共价方法制备了一种新型的GO-hypocrellin A（GO-HA）杂种，并首次研究了其光动力活性。结果表明，HA在GO上的有效负载量高达1.0 mg mg〜（-1），杂合体的稳定性优于水溶液中游离的hypercrylinA。此外，可以通过用适当波长的光照射来激发GO-HA以产生单线态氧，并且体外实验表明GO-HA被肿瘤细胞有效地吸收，并且这种浸渍细胞的光照射导致明显的细胞死亡。 。因此，GO-HA的这些特性可能使其在临床光动力疗法中特别有前途。

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