Palladium-catalyzed asymmetric quaternary stereocenter formation

Gottumukkala A.L.; Matcha K.; Lutz M.; De Vries J.G.; Minnaard A.J.

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Palladium-catalyzed asymmetric quaternary stereocenter formation

机译：钯催化的不对称四元立体中心形成

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An efficient palladium catalyst is presented for the formation of benzylic quaternary stereocenters by conjugate addition of arylboronic acids to a variety of β,β-disubstituted carbocyclic, heterocyclic, and acyclic enones. The catalyst is readily prepared from PdCl _2, PhBOX, and AgSbF _6, and provides products in up to 99 % enantiomeric excess, with good yields. Based on this strategy, (-)-α-cuparenone has been prepared in only two steps.

机译：通过将芳基硼酸共轭加成到各种β，β-二取代的碳环，杂环和无环烯酮上，提出了一种有效的钯催化剂，用于形成苄基的季立体中心。该催化剂易于从PdCl _2，PhBOX和AgSbF _6制备，并以高达99％的对映体过量提供产物。基于此策略，仅需两个步骤即可制备（-）-α-cuparenone。

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《Chemistry: A European journal》 |2012年第22期|共8页
作者
Gottumukkala A.L.; Matcha K.; Lutz M.; De Vries J.G.; Minnaard A.J.;
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正文语种 eng
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arylboronic acids; cuparenone; Michael addition; palladium; quaternary stereocenters;

机译：芳基硼酸;Cuparenone;Michael加成;钯;季立体中心;

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1. Palladium-catalyzed asymmetric quaternary stereocenter formation [J] . Gottumukkala A.L., Matcha K., Lutz M., Chemistry: A European journal . 2012,第22期

机译：钯催化的不对称四元立体中心形成
2. Chiral alpha-Amino Acid/Palladium-Catalyzed Asymmetric Allylation of alpha-Branched beta-Ketoesters with Allylic Amines: Highly Enantioselective Construction of All-Carbon Quaternary Stereocenters [J] . Xu Ya-Nan, Zhu Meng-Zeng, Tian Shi-Kai The Journal of Organic Chemistry . 2019,第22期

机译：手性α-氨基酸/钯催化的α-支链β-酮酯的不对称烯丙基酯，具有烯胺胺：全碳季度立体中心的高度映射性构建
3. Enantioselective Construction of Quaternary Carbon Stereocenter via Palladium-Catalyzed Asymmetric Allylic Alkylation of Lactones [J] . Li Xiao-Hui, Wan Shi-Li, Chen Di, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2016,第10期

机译：钯催化内酯的不对称烯丙基烷基化对映选择性构建季碳立体中心
4. Catalytic Asymmetric Construction of Quaternary Stereocenters through Rhodium-Catalyzed Addition of Organoboronic Acids [C] . Ryo Shintani, Wei-Liang Duan, Mitsunori Inoue Symposium on Organometallic Chemistry . 2006

机译：通过铑催化加入有机硼酸催化不对称结构的季型立体封闭
5. I. Studies on the organocatalytic formation of quaternary stereocenters. ii. Studies on the claisen rearrangement as a route to quaternary stereocenters. iii. Asymmetric synthesis of aldehydes bearing quaternary carbon centers via the decarboxylative asymmetric allylic alkylation. [D] . Alberch, Eduardo. 2013

机译：I.季铵立体中心的有机催化形成研究。 ii。关于克莱森重排作为四元立体中心路径的研究。 iii。通过脱羧不对称烯丙基烷基化反应不对称合成带有季碳中心的醛。
6. Palladium-Catalyzed Asymmetric Construction of Vicinal All-Carbon Quaternary Stereocenters and its Application to the Synthesis of Cyclotryptamine Alkaloids [O] . Prof. Barry M. Trost, Maksim Osipov -1

机译：钯催化的全碳四元立体中心的不对称结构及其在环丙烯胺生物碱合成中的应用
7. Berichtigung: Palladium-Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Michael Acceptors: Construction of Vicinal Quaternary Stereocenters [O] . Ajmal Khan, Lei Yang, Jing Xu, 2015

机译：Berichtigung：钯催化的不对称脱羧环加乙烯基碳酸丁酯与迈克尔受体：张视季度立体中心的构建

Palladium-catalyzed asymmetric quaternary stereocenter formation

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