Lewis base assisted Br?nsted base catalysis: Direct regioselective asymmetric vinylogous alkylation of allylic sulfones

Jiang L.; Lei Q.; Huang X.; Cui H.-L.; Zhou X.; Chen Y.-C.

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Lewis base assisted Br?nsted base catalysis: Direct regioselective asymmetric vinylogous alkylation of allylic sulfones

机译：Lewis碱辅助的Br？nsted碱催化：烯丙基砜的直接区域选择性不对称乙烯基烷基化

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A Lewis base assisted Br?nsted base catalysis (LBABB) strategy is applied for direct asymmetric vinylogous alkylation of allylic sulfones with Morita-Baylis-Hillman (MBH) carbonates, in which a strong Br?nsted base, tert-butoxy anion, generated in situ from a tertiary amine catalyst and MBH carbonate, is crucial in activating unstabilized nucleophiles. The γ-regioselective alkylation products were obtained with good to excellent enantiomeric excess values when catalyzed by a modified cinchona alkaloid.

机译：刘易斯碱辅助的布朗斯台德碱催化（LBABB）策略被用于与森田-贝利斯-希尔曼（MBH）碳酸酯进行烯丙基砜的直接不对称乙烯基烷基化反应，其中生成了强布朗斯泰德碱，叔丁氧基阴离子。来自叔胺催化剂和MBH碳酸酯的原位反应对于活化不稳定的亲核试剂至关重要。当用修饰的金鸡纳生物碱催化时，获得的γ-区域选择性烷基化产物具有良好的至优异的对映体过量值。

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《Chemistry: A European journal》 |2011年第34期|共5页
作者
Jiang L.; Lei Q.; Huang X.; Cui H.-L.; Zhou X.; Chen Y.-C.;
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正文语种 eng
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alkylation; allylic sulfones; Br?nsted bases; Lewis bases; Morita-Baylis-Hillman carbonates;

机译：烷基化;烯丙基砜;布朗斯台德碱;刘易斯碱;Morita-Baylis-Hillman碳酸盐;

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1. Lewis base assisted Br?nsted base catalysis: Direct regioselective asymmetric vinylogous alkylation of allylic sulfones [J] . Jiang L., Lei Q., Huang X., Chemistry: A European journal . 2011,第34期

机译：Lewis碱辅助的Br？nsted碱催化：烯丙基砜的直接区域选择性不对称乙烯基烷基化
2. Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft Lewis Acid/Hard Brønsted Base/Hard Lewis Base Catalysis [J] . Ryo Yazaki Naoya Kumagai* and Masakatsu Shibasaki Journal of the American Chemical Society . 2010,第15期

机译：通过软路易斯酸/硬布朗斯台德碱/硬路易斯碱催化直接将烯丙基氰化物催化不对称加成酮
3. Lewis Base Assisted Lithium Br?nsted Base Catalysis: A New Entry for Catalytic Asymmetric Synthesis of β2,2-Amino Acids [J] . Fuyuki Amemiya, Hidetoshi Noda, Masakatsu Shibasaki Chemical and Pharmaceutical Bulletin . 2019,第10期

机译：Lewis碱辅助的锂布朗斯台德碱催化：β2,2-氨基酸催化不对称合成的新途径
4. Direct Allylic C?H Alkylation of Enol Silyl Ethers Enabled by Photoredox-Bronsted Base Hybrid Catalysis [C] . NAKASHIMA Tsubasa, OHMATSU Kohsuke, OOI Takashi 日本化学会春季年会講演予稿集 . 2018

机译：直接烯丙基C-H烷基化烯醇甲硅烷基醚化的光毒氧化物基杂交催化催化
5. Acyl imidazole: A promising template for asymmetric Lewis and Brønsted acid mediated 1,3-dipolar cycloadditions [D] . Rane, Digamber Sadanand 2011

机译：酰基咪唑：不对称路易斯和布朗斯台德酸介导的1，3-偶极环加成反应的有前途的模板
6. Direct allylic C–H alkylation of enol silyl ethers enabled by photoredox–Brønsted base hybrid catalysis [O] . Kohsuke Ohmatsu, Tsubasa Nakashima, Makoto Sato, -1

机译：通过光氧化还原-布朗斯台德碱杂化催化实现烯醇甲硅烷基醚的直接烯丙基CH烷基化
7. 1,1,3,3-Tetratriflylpropene (TTP): A Strong, Allylic C–H Acid for Brønsted and Lewis Acid Catalysis [O] . Höfler, D., van Gemmeren, M., Wedemann, P., 2017

机译：1,1,3,3-四丙烯基丙烯（TTp）：一种强的烯丙基C-H酸，用于布朗斯台德和路易斯酸催化

Lewis base assisted Br?nsted base catalysis: Direct regioselective asymmetric vinylogous alkylation of allylic sulfones

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