Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls

Kenwright J.L.; Galloway W.R.J.D.; Blackwell D.T.; Isidro-Llobet A.; Hodgkinson J.; Wortmann L.; Bowden S.D.; Welch M.; Spring D.R.

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Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls

机译：新型和高效的铜催化合成氮连接的中环联芳基

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Herein, a new copper-catalysed strategy for the synthesis of rare nitrogen-linked seven-, eight- and nine-membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co-ordinated copper catalyst. The process is technically simple, proceeds under relatively mild conditions, displays a broad substrate scope and forms biologically valuable products that are difficult to synthesise by other methods. We envisage that this methodology will prove useful in a wide synthetic context, with possible applications in both target-oriented and diversity-oriented synthesis.

机译：在此，描述了用于稀有氮连接的七元，八元和九元联芳环体系的合成的新的铜催化策略。提出该反应通过高度活化的分子内配位的铜催化剂进行。该方法技术上简单，在相对温和的条件下进行，显示出广泛的底物范围，并形成了难以通过其他方法合成的具有生物学价值的产物。我们设想，该方法论将在广泛的综合环境中证明是有用的，并可能在面向目标和面向多样性的综合中应用。

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《Chemistry: A European journal》 |2011年第10期|共6页
作者
Kenwright J.L.; Galloway W.R.J.D.; Blackwell D.T.; Isidro-Llobet A.; Hodgkinson J.; Wortmann L.; Bowden S.D.; Welch M.; Spring D.R.;
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正文语种 eng
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关键词
antibiotics; biaryls; copper; medium-ring compounds; synthetic methods;

机译：抗生素;联芳基;铜;中环化合物;合成方法;

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1. Novel and Efficient Copper-Catalysed Synthesis of Nitrogen-Linked Medium-Ring Biaryls [J] . Dr. Jayne L. Kenwright, Dr. Warren R. J. D. Galloway, Dr. David T. Blackwell, Chemistry - A European Journal . 2011,第10期

机译：新型和高效的铜催化氮连接的中环联芳烃
2. Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products [J] . Xianbin Su, Gemma L. Thomas, Warren R. J. D. Galloway, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2009,第22期

机译：有机酸氧化法合成含联芳基的中环体系：在鞣花宁天然产物的全合成中的应用
3. Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products [J] . Xianbin Su, Gemma L. Thomas, Warren R. J. D. Galloway, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2009,第22期

机译：通过有机化碳氧化合成含芳基的中环系统：在素鞣蛋白天然产物的总合成中的应用
4. Inhibition of yeast 20S proteasome by biaryl- and biaryl ether-cross-bridged tripeptide derivatives as TMC-95A analogs [C] . Markus Kaiser, Michael Groll, Carlo Siciliano, Chinese Peptide Symposium; 20040703-06; Kunming(CN) . 2004

机译：联芳基和联芳基醚交联的三肽衍生物作为TMC-95A类似物对酵母20S蛋白酶体的抑制作用
5. An application of the intramolecular Heck reaction: A new strategy in the synthesis of Hasubanan alkaloids. Preparation of unsymmetrical biaryls via the Stille cross-coupling reaction: Synthesis of highly functional intermediates towards the synthesis of vindoline. [D] . Frank, Anthony Joseph. 2002

机译：分子内Heck反应的应用：合成Hasubanan生物碱的新策略。通过Stille交叉偶联反应制备不对称的联芳基：合成高功能性中间体，合成长春新碱。
6. Asymmetric synthesis of biaryl atropisomers by dynamic resolution on condensation of biaryl aldehydes with (−)-ephedrine or a proline-derived diamine [O] . Ann Bracegirdle, Jonathan Clayden, Lai Wah Lai 2008

机译：通过动态拆分联芳基醛与（-）-麻黄碱或脯氨酸衍生的二胺的缩合反应动态合成联芳基阻转异构体
7. An Efficient and Versatile Approach for Optical Resolution of C2-Symmetric Axially Chiral Biaryl Dials. Synthesis of Enantiopure Biaryl-Derived Cyclic trans-1,2-Diols [O] . -1

机译：C2对称轴向手性前列拨号光学分辨率有效且多功能的方法。对映致苯芳基衍生的环状反式1,2-二醇的合成

Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls

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