Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment

Trost B.M.; Yang H.; Dong G.

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Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment

机译：bryostatins的总合成：两种环膨胀的bryostatin类似物的合成以及开发新一代访问C7-C27片段的策略

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Herein, we report the synthesis of novel ring-expanded bryostatin analogues. By carefully modifying the substrate, a selective and high-yielding Ru-catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring-closing metathesis was utilized to form the 31-membered ring macrocycle of the analogue. These ring-expanded bryostatin analogues possess anticancer activity against several cancer cell lines. Given the difficulty in forming the C16-C17 olefin at a late stage, we also describe our development of a new-generation strategy to access the C7-C27 fragment, containing both the ring B and C subunits.

机译：在这里，我们报告了新型环膨胀的bryostatin类似物的合成。通过仔细修饰底物，采用选择性和高产率的Ru催化的串联烯炔偶联/ Michael加成来构建Northern片段。利用闭环复分解形成类似物的31元环大环。这些环膨胀的抑菌素类似物具有针对几种癌细胞的抗癌活性。鉴于在后期阶段难以形成C16-C17烯烃，我们还描述了开发新一代策略以开发同时包含环B和C亚基的C7-C27片段的方法。

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《Chemistry: A European journal》 |2011年第35期|共17页
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Trost B.M.; Yang H.; Dong G.;
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正文语种 eng
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bryostatins; domino reactions; metathesis; palladium; ruthenium;

机译：溴抑制素;多米诺骨反应;易位;钯;钌;

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1. Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment [J] . Trost B.M., Yang H., Dong G. Chemistry: A European journal . 2011,第35期

机译：bryostatins的总合成：两种环膨胀的bryostatin类似物的合成以及开发新一代访问C7-C27片段的策略
2. Total Synthesis of Bryostatin 16 Using a Pd-Catalyzed Diyne Coupling as Macrocyclization Method and Synthesis of C20-epi-Bryostatin 7 as a Potent Anticancer Agent [J] . Barry M. Trost, Guangbin Dong Journal of the American Chemical Society . 2010,第46期

机译：以Pd催化的二炔偶联为大环化方法的Bryostatin 16的全合成和强效抗癌剂C20-epi-Bryostatin 7的合成
3. SYNTHETIC STUDIES ON BRYOSTATINS, POTENT ANTINEOPLASTIC AGENTS - SYNTHESIS OF THE C-17-C-27 FRAGMENT OF C-20 OXYGENATED BRYOSTATINS [J] . Ohmori K., Yamamura S., Nishiyama S. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1995,第36期

机译：苔藓抑素，强效抗肿瘤剂的合成研究-C-20氧化苔藓抑素的C-17-C-27片段的合成
4. Total Syntheses of Miraziridine A and Its Analogues [C] . Hiroyuki Konno, Kanako Kubo, Hidefumi Makabe International Peptide Symposium . 2009

机译：米拉基吖啶A及其类似物的总合成
5. The large scale synthesis of the C19 to C32 portion of swinholide A, the total synthesis of dactylolide, and the synthesis of a novel bryostatin analogue. [D] . Sanchez, Carina Cristina. 2005

机译：Swinholide A的C19至C32部分的大规模合成，环己内酯的总合成以及新型的抑菌素类似物的合成。
6. Total Syntheses of Bryostatins. Syntheses of Two Ring-Expanded Bryostatin Analogues and Development of a New-Generation Strategy to Access the C7-C27 Fragment [O] . Dr. Barry M. Trost, Hanbiao Yang, Guangbin Dong -1

机译：苔藓抑素总合成。两个环形扩张的苔藓抑素类似物的合成和开发新一代策略用于访问C7-C27片段
7. Synthesis of a Ring-Expanded Bryostatin Analogue [O] . -1

机译：环形膨胀苔藓抑素类似物的合成

Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment

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