• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Isolation, structure determination, and synthesis of allo-RA-V and neo-RA-V, RA-series bicyclic peptides from Rubia cordifolia L.
【24h】

Isolation, structure determination, and synthesis of allo-RA-V and neo-RA-V, RA-series bicyclic peptides from Rubia cordifolia L.

机译：茜草（Rubia cordifolia L）的异源RA-V和neo-RA-V，RA系列双环肽的分离，结构测定和合成。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two bicyclic hexapeptides, allo-RA-V (4) and neo-RA-V (5), and one cyclic hexapeptide, O-seco-RA-V (6), were isolated from the roots of Rubia cordifolia L. Their gross structures were elucidated on the basis of spectroscopic analysis and X-ray crystallography of compound 5. The absolute stereochemistry of compounds 4 and 5 were established by their total syntheses, and the absolute stereochemistry of compound 6 by chemical correlation with deoxybouvardin (3). Comparison of the 3D structures of highly active RA-VII (1) with less-active compounds 4 and 5 suggests that the orientation of the Tyr-5 and/or Tyr-6 phenyl rings plays a significant role in their biological activity. The isolation of peptides 4-6, along with compound 3, and the comparison of their structures seem to indicate that peptide 6 may be the common precursor to bicyclic peptides 3-5 in the plant. Allo allo: Two cycloisodityrosine-modified congeners of deoxybouvardin (RA-V) have been isolated from the roots of Rubia cordifolia. Comparison of their structures with that of RA-VII revealed that the orientation of one or both of the Tyr-5 and Tyr-6 phenyl rings plays an essential role in expressing the cytotoxic activity.
机译：从茜草的根中分离出两个双环六肽，即异源RA-V（4）和neo-RA-V（5），和一个环六肽，O-seco-RA-V（6）。通过光谱分析和化合物5的X射线晶体学阐明了化合物的结构。化合物4和5的绝对立体化学是通过它们的总合成建立的，化合物6的绝对立体化学是通过与脱氧布瓦丁的化学相关性确定的（3）。高活性RA-VII（1）与活性较低的化合物4和5的3D结构比较表明，Tyr-5和/或Tyr-6苯环的取向在其生物活性中起重要作用。肽4-6和化合物3的分离以及它们的结构比较似乎表明，肽6可能是植物中双环肽3-5的常见前体。 Allo allo（同种异体）：已从茜草的根中分离出两个环氧异丁烷修饰的脱氧布瓦丁（RA-V）同系物。它们的结构与RA-VII的结构比较表明，Tyr-5和Tyr-6苯环之一或二者的取向在表达细胞毒性活性中起着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号