Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp.

Almeida C.; Hemberger Y.; Schmitt S.M.; Bouhired S.; Natesan L.; Kehraus S.; Dimas K.; Gütschow M.; Bringmann G.; K?nig G.M.

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Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp.

机译：Marilines A-C：海绵衍生真菌Stachylidium sp。的新型邻苯二甲酰亚胺。

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A marine-derived fungus of the genus Stachylidium was isolated from the sponge Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the isolation of the novel phthalimidine derivatives marilines A _1 (1 a), A _2 (1 b), B (2), and C (3). The absolute configurations of the enantiomeric compounds 1 a and 1 b were assigned by a combination of experimental circular dichroism (CD) investigations and quantum chemical CD calculations. The skeleton of marilines is most unusual, and its biosynthesis is suggested to require uncommon biochemical reactions in fungal secondary metabolism. Both enantiomers, marilines A _1 (1 a) and A _2 (1 b), inhibited human leukocyte elastase (HLE) with an IC _(50) value of 0.86 μM.

机译：从海绵Callyspongia cf.分离到了一种来自海洋的水苏属真菌。 C. flammea。对生物活性真菌提取物的化学研究导致分离出新型邻苯二甲酰亚胺衍生物海事碱A _1（1 a），A _2（1 b），B（2）和C（3）。对映体化合物1a和1b的绝对构型是通过实验圆二色性（CD）研究和量子化学CD计算的组合确定的。海水的骨骼是最不寻常的，建议其生物合成在真菌的次级代谢中需要罕见的生化反应。两种对映异构体，分别为海水A _1（1 a）和A _2（1 b），均抑制人白细胞弹性蛋白酶（HLE），IC _（50）值为0.86μM。

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《Chemistry: A European journal》 |2012年第28期|共8页
作者
Almeida C.; Hemberger Y.; Schmitt S.M.; Bouhired S.; Natesan L.; Kehraus S.; Dimas K.; Gütschow M.; Bringmann G.; K?nig G.M.;
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CD spectroscopy; human leukocyte elastase; marine fungus; phthalimidine; Stachylidium;

机译：CD光谱法;人白细胞弹性蛋白酶;海洋真菌;邻苯二甲酰亚胺;棘孢菌属;

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1. Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp. [J] . Almeida C., Hemberger Y., Schmitt S.M., Chemistry: A European journal . 2012,第28期

机译：Marilines A-C：海绵衍生真菌Stachylidium sp。的新型邻苯二甲酰亚胺。
2. Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04 [J] . El Maddah Fayrouz, Eguereva Ekaterina, Kehraus Stefan, Organic & biomolecular chemistry . 2019,第10期

机译：海洋海绵衍生真菌Stachylidium sp。的新型聚酮化合物的生物合成研究。 293K04
3. Stachylines A-D from the sponge-derived fungus Stachylidium sp. [J] . Almeida C, Part N, Bouhired S, Journal of natural products . 2011,第1期

机译：来自海绵真菌Stachylidium sp。的水苏属A-D。
4. Identification of a Potential IAA-Producing Fungus Isolated From Alpinia Sp. Rhizome in Hutan Sibayak, North Sumatera [C] . Adrian Hartanto, Anisa Lutfia, Erman Munir, Universitas Riau International Conference on Science and Environment . 2020

机译：鉴定从alpinia sp分离的潜在的潜在的生成菌真菌。在Hutan Sibayak，北苏马特的根茎
5. Symbiotic effects of the fungus Glomus sp. on chromium(III), chromium(VI), and lead(II) uptake by mesquite (Prosopis sp.): A novel method to remediate heavy metals. [D] . Arias, Jack A. 2009

机译：真菌Glomus sp。的共生效应。豆科植物（Prosopis sp。）对铬（III），铬（VI）和铅（II）的吸收：一种修复重金属的新方法。
6. Marilones A–C phthalides from the sponge-derived fungus Stachylidium sp. [O] . Celso Almeida, Stefan Kehraus, Miguel Prudêncio, 2011

机译：Marilones A–C来自海绵真菌Stachylidium sp。的邻苯二甲酸盐。
7. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04 [O] . Celso Almeida, Gerald Bills, Víctor González-Menéndez, 2017

机译：生物活性肽的时间依赖性生产含有a和b和聚酮化酮的马里林A来自海绵衍生的真菌stachylidium bicolor 293k04

Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp.

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