Unprecedented torsional preferences in trans-β ~(2,3)-amino acid residues and formation of 11-helices in α,β ~(2,3)-hybrid peptides

Balamurugan D.; Muraleedharan K.M.

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Unprecedented torsional preferences in trans-β ~(2,3)-amino acid residues and formation of 11-helices in α,β ~(2,3)-hybrid peptides

机译：反式β〜（2,3）-氨基酸残基空前的扭转偏好以及α，β〜（2,3）-杂合肽中11螺旋的形成

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摘要

Anti or gauche? trans-β ~(2,3)-Amino acid residues that are known to promote extended structures in their peptides show specific rotamer preferences in response to an intramolecular hydrogen-bonding possibility, which facilitates the 11-helical structures in their 1:1 α,β-hybrid peptides (see figure). Preferences for the gauche conformation for all internal β residues and anti for the C-terminal residue in these peptides were confirmed by NMR spectroscopic and X-ray diffraction experiments.

机译：防还是薄纱？反-β〜（2,3）-已知可促进其肽中扩展结构的氨基酸残基在响应分子内氢键的可能性时表现出特定的rotamer偏好，从而促进其1：1α的11螺旋结构，β-杂合肽（见图）。通过NMR光谱和X射线衍射实验证实了这些肽中所有内部β残基的gauche构象的偏爱和C末端的抗gauche构象的偏爱。

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《Chemistry: A European journal》 |2012年第31期|共5页
作者
Balamurugan D.; Muraleedharan K.M.;
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正文语种 eng
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α/β-hybrid peptides; β-amino acids; foldamers; helical structures; NMR spectroscopy;

机译：α/β杂合肽;β-氨基酸;折叠剂;螺旋结构;NMR光谱;

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1. Unprecedented torsional preferences in trans-β ~(2,3)-amino acid residues and formation of 11-helices in α,β ~(2,3)-hybrid peptides [J] . Balamurugan D., Muraleedharan K.M. Chemistry: A European journal . 2012,第31期

机译：反式β〜（2,3）-氨基酸残基空前的扭转偏好以及α，β〜（2,3）-杂合肽中11螺旋的形成
2. Structural chemistry of peptides containing backbone expanded amino acid residues: Conformational features of β, γ, and hybrid peptides [J] . Vasudev P.G., Chatterjee S., Narayanaswamy S., Chemical Reviews . 2011,第2期

机译：包含骨架扩展的氨基酸残基的肽的结构化学：β，γ和杂合肽的构象特征
3. Hybrid Peptide Design. Hydrogen Bonded Conformations in Peptides Containing the Stereochemically Constrained γ-Amino Acid Residue, Gabapentin [J] . Prema G. Vasudev, Kuppanna Ananda, Sunanda Chatterjee, Journal of the American Chemical Society . 2007,第13期

机译：杂合肽设计。含有立体化学约束的γ-氨基酸残基加巴喷丁的肽中的氢键构象
4. SUGAR AMINO ACIDS - SYNTHESIS AND CONFORMATIONAL ANALYSIS OF DIMETHYL 3-AMINO-2,3-DIDEOXYHEXOPYRANOSIDURONATES [C] . Beata Liberek, Dorota Tuwalska, Antoni Konitz the European Peptide Symposium . 2007

机译：糖氨基酸 - 二甲基3-氨基-2,3-二赤氧基吡喃醇酸酯的合成和构象分析
5. Amino acids as chiral templates in the stereoselective syntheses of bioactive compounds: I. Stereoselective routes to 2,3-disubstituted piperidines. II. Synthetic studies on polyoxin J. [D] . Liang, Ningning. 2006

机译：氨基酸作为生物活性化合物立体选择性合成中的手性模板：I.立体选择性合成2,3-二取代哌啶的途径。二。多聚毒素J的合成研究。
6. Hybrid Peptide Hairpins Containing α- and ω-Amino Acids: Conformational Analysis of Decapeptides with Unsubstituted β- γ- and δ-Residues at Positions 3 and 8 [O] . Rituparna S. Roy, Hosahudya N. Gopi, Srinivasarao Raghothama, -1

机译：包含α-和ω-氨基酸的杂合肽发夹：十肽在3和8位上具有未取代的β-γ-和δ-残基的构象分析
7. Conformations of b-Amino Acid Residues in Peptides: X-Ray Diffraction Studies of Peptides Containing the Achiral Residue 1-Aminocyclohexaneacetic Acid, b3,3Ac6c [O] . Prema G. Vasudev, Rajkishor Rai, Narayanaswamy Shamala, 2015

机译：肽中b-氨基酸残基的构象：含有非手性残基1-氨基环己烷乙酸，b3,3ac6c的肽的X射线衍射研究
8. Reaction of Bis(triethylphosphine)Platinum and Pentakis(t-butyl isocyanide)-Ruthenium with Dicarba-nido-hexaboranes(8): Molecular Structures of (Nido-micron(4,5)-(Trans-(Et3P)2 Pt(H))-micron(5,6)-H-2,3-C2B4H6), (Closo-1,1-(Et3P)2-2,3-Me2-1,2,3-PtC2B4H4), and (RuH(ButNC)5)(+) (Nido-2,3-Me2-2,3-C2B4H5)(-). [R] . Barker, G. K., Green, M., Onak, T. P., 1977

机译：双（三乙基膦）铂和pentakis（叔丁基异氰化物） - 钌与Dicarba-nido-hexaboranes的反应（8）：（Nido-微米（4,5） - （反式 - （Et3p）2 pt（H）的分子结构）） - 微米（5,6）-H-2,3-C2B4H6），（Closo-1,1-（Et3p）2-2,3-me2-1,2,3-ptC2B4H4）和（RuH（但NC）5）（+）（Nido-2,3-me2-2,3-C2B4H5）（ - ）。

Unprecedented torsional preferences in trans-β ~(2,3)-amino acid residues and formation of 11-helices in α,β ~(2,3)-hybrid peptides

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