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首页> 外文期刊>Chemistry: A European journal >Hemin-functionalized reduced graphene oxide nanosheets reveal peroxynitrite reduction and isomerization activity
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Hemin-functionalized reduced graphene oxide nanosheets reveal peroxynitrite reduction and isomerization activity

机译：血红素官能化的还原氧化石墨烯纳米片揭示了过氧亚硝酸盐的还原和异构化活性

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摘要

Facile and efficient reduction of graphene oxide (GO) and novel applications of the reduced graphene oxide (RGO) based materials are of current interest. Herein, we report a novel and facile method for the reduction of GO by using a biocompatible reducing agent dithiothreitol (DTT). Stabilization of DTT by the formation of a six-membered ring with internal disulfide linkage upon oxidation is responsible for the reduction of GO. The reduced graphene oxide is characterized by several spectroscopic and microscopic techniques. Dispersion of RGO in DMF remained stable for several weeks suggesting that the RGO obtained by DTT-mediated reduction is hydrophobic in nature. This method can be considered for large scale production of good quality RGO. Treatment of RGO with hemin afforded a functional hemin-reduced graphene oxide (H-RGO) hybrid material that exhibited remarkable protective effects against the potentially harmful peroxynitrite (PN). A detailed inhibition study on PN-mediated oxidation and nitration reactions indicate that the interaction between hemin and RGO results in a synergistic effect, which leads to an efficient reduction of PN to nitrate. The RGO also catalyzes the isomerization of PN to nitrate as the RGO layers facilitate the rapid recombination of.NO_2 with Fe~(IV)=O species. In the presence of reducing agents such as ascorbic acid, the Fe~(IV)=O species can be reduced to Fe~(III), thus helping to maintain the PN reductase cycle.
机译：简便有效地还原氧化石墨烯（GO）和基于还原氧化石墨烯（RGO）的材料的新应用是当前的关注点。在本文中，我们报告了一种新型且简便的方法，可通过使用生物相容性还原剂二硫苏糖醇（DTT）来还原GO。通过在氧化时形成带有内部二硫键的六元环来稳定DTT是GO还原的原因。还原的氧化石墨烯的特征在于几种光谱学和显微技术。 RGO在DMF中的分散保持稳定数周，这表明通过DTT介导的还原获得的RGO本质上是疏水的。对于大规模生产高质量RGO，可以考虑使用此方法。用血红素处理RGO可得到功能性的血红素还原型氧化石墨烯（H-RGO）杂化材料，对潜在有害的过氧亚硝酸盐（PN）表现出显着的保护作用。对PN介导的氧化和硝化反应的详细抑制研究表明，血红素和RGO之间的相互作用会产生协同效应，从而导致PN有效还原为硝酸盐。 RGO还催化PN异构化为硝酸盐，因为RGO层促进了NO_2与Fe〜（IV）= O物种的快速重组。在还原剂如抗坏血酸的存在下，Fe〜（IV）= O物种可以还原为Fe〜（III），从而有助于维持PN还原酶循环。

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