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首页> 外文期刊>Chemistry: A European journal >Catalytic Reduction of Graphene Oxide Nanosheets by Glutathione Peroxidase Mimetics Reveals a New Structural Motif in Graphene Oxide
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Catalytic Reduction of Graphene Oxide Nanosheets by Glutathione Peroxidase Mimetics Reveals a New Structural Motif in Graphene Oxide

机译：谷胱甘肽过氧化物酶模拟物催化还原氧化石墨烯纳米片揭示了氧化石墨烯中的新结构基元。

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A catalytic reduction of graphene oxide (GO) by glutathione peroxidase (GPx) mimics is reported. This study reveals that GO contains peroxide functionalities, in addition to the epoxy, hydroxyl and carboxylic acid groups that have been identified earlier. It also is shown that GO acts as a peroxide substrate in the GPx-like catalytic activity of organoselenium/tellurium compounds. The reaction of tellurol, generated from the corresponding ditelluride, reduces GO through the glutathione (GSH)-mediated cleavage of the peroxide linkage. The mechanism of GO reduction by the tellurol in the presence of GSH involves the formation of a tellurenic acid and tellurenyl sulfide intermediates. Interestingly, the GPx mimics also catalyze the decarboxylation of the carboxylic acid functionality in GO at ambient conditions. Whereas the selenium/telluriummediated catalytic reduction/decarboxylation of GO may find applications in bioremediation processes, this study suggests that the modification of GO by biologically relevant compounds such as redox proteins must be taken into account when using GO for biomedical applications because such modifications can alter the fundamental properties of GO.
机译：据报道，谷胱甘肽过氧化物酶（GPx）模拟物催化还原氧化石墨烯（GO）。这项研究表明，GO包含过氧化物官能团，此外还包括较早发现的环氧，羟基和羧酸基团。还显示GO在有机硒/碲化合物的GPx样催化活性中充当过氧化物底物。由相应的二碲化物产生的碲的反应通过谷胱甘肽（GSH）介导的过氧化物键合的裂解而降低了GO。谷胱甘肽在GSH存在下GO还原GO的机制涉及形成碲酸和碲烯基硫化物中间体。有趣的是，GPx模拟物还可以在环境条件下催化GO中羧酸官能团的脱羧反应。尽管硒/碲介导的GO催化还原/脱羧可以在生物修复过程中找到应用，但这项研究表明，在将GO用于生物医学应用时，必须考虑生物相关化合物（例如氧化还原蛋白）对GO的修饰，因为这种修饰会改变GO的基本属性。

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