Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides

Kuang Y.; Sun H.; Blain J.C.; Peng X.

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Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides

机译：缺氧选择性DNA链间交联的两个修饰的核苷形成。

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The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.

机译：干净的交叉密码：合成了两个硝基咪唑修饰的胸苷1a和1b，并将其掺入DNA寡聚物中。 1a和1b的350 nm光解产生了一个5-（2'-deoxyuridinyl）methyl基团，该基团引起DNA链间交联（ICL;请参见方案）。缺氧条件下的ICL产量高于有氧条件下的ICL产量。

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《Chemistry: A European journal》 |2012年第40期|共5页
作者
Kuang Y.; Sun H.; Blain J.C.; Peng X.;
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正文语种 eng
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关键词
DNA cross-linking; DNA damage; nucleic acids; nucleosides; UV photolysis;

机译：DNA交联;DNA损伤;核酸;核苷;紫外光解;

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1. Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides [J] . Kuang Y., Sun H., Blain J.C., Chemistry: A European journal . 2012,第40期

机译：缺氧选择性DNA链间交联的两个修饰的核苷形成。
2. 4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA [J] . Atsushi Nishimoto, Daichi Jitsuzaki, Kazumitsu Onizuka, Nucleic Acids Research . 2013,第13期

机译：4-乙烯基取代的嘧啶核苷表现出与RNA和双链DNA的链间交联的有效和选择性形成
3. 4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA [J] . Atsushi Nishimoto, Daichi Jitsuzaki, Fumi Nagatsugi, Nucleic acids research . 2013,第13期

机译：4-乙烯基取代的嘧啶核苷表现出与RNA和双链DNA高效有效地形成链间交联的作用
4. Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Cross-link Repair [C] . Ji Jiang, Lin Li, Pengcheng Wang, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：亚砷酸盐与FANCL E3泛素连接酶的铃声域粘合并抑制DNA Interstrand Cross-Link修复
5. DNA-Protein Cross-links: Formation in Cells and Tissues, Repair, and Inhibition of DNA Transcription [D] . Park, Daeyoon 2019

机译：DNA蛋白质交联：在细胞和组织中的形成，修复和DNA转录的抑制。
6. Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides [O] . Dr. Yunyan Kuang, Dr. Huabing Sun, Dr. J. Craig Blain, -1

机译：两种改性核苷的缺氧选择性DNA Interstrand交联形成
7. Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts [O] . B Behmand, A M Noronha, C J Wilds, 2020

机译：水合电子诱导由顺铂加合物改性的DNA中的Interstrand交联的形成

Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides

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