A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

Suntharalingam K.; ?czkowska A.; Furrer M.A.; Wu Y.; Kuimova M.K.; Therrien B.; White A.J.P.; Vilar R.

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A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

机译：环金属化铂络合物作为四链DNA的选择性光开关

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Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.

机译：热门：据报道，具有取代的菲咯啉配体的环金属化铂（II）配合物。该复合物对四链体DNA具有很高的体外亲和力，一旦结合，其发射就开启了。通过使用金属笼作为载体，可以轻松将复合物递送至细胞（参见插图）。通过共聚焦显微镜，表明复合物在细胞内释放，穿透细胞核并位于核仁中。

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《Chemistry: A European journal》 |2012年第51期|共6页
作者
Suntharalingam K.; ?czkowska A.; Furrer M.A.; Wu Y.; Kuimova M.K.; Therrien B.; White A.J.P.; Vilar R.;
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正文语种 eng
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关键词
G-quadruplexes; host-guest interactions; molecular cages; optical imaging; platinum;

机译：G-四链体;宿主-客体相互作用;分子笼;光学成像;铂;

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1. A cyclometallated platinum complex as a selective optical switch for quadruplex DNA [J] . Suntharalingam K., ?czkowska A., Furrer M.A., Chemistry: A European journal . 2012,第51期

机译：环金属化铂络合物作为四链DNA的选择性光开关
2. Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders [J] . Kieltyka R, Fakhoury J, Moitessier N, Chemistry: A European journal . 2008,第4期

机译：铂菲并咪唑配合物作为G-四链体DNA选择性结合剂
3. Cyclometallated platinum(II) complexes containing pyridyl-acetylide ligands: the selective influence of lead binding on luminescence [J] . Lanoe PH, Le Bozec H, Williams JAG, Dalton transactions: An international journal of inorganic chemistry . 2010,第3期

机译：含吡啶基-乙炔基配体的环金属化铂（II）配合物：铅结合对发光的选择性影响
4. Anticancer activity of platinum(Ⅱ) complex as G-quadruplex DNA Binders [C] . Qipin Qin, Yulan Li, Yancheng Liu, International Conference on Chemical Engineering and Advanced Materials . 2013

机译：铂（Ⅱ）复合物作为G-QuadrepleDNA粘合剂的抗癌活性
5. Part I. Circular DNAs as switchable DNA-binding agents. Part II. Highly selective and sensitive oligonucleotide probes [D] . Paris, Pamela Lynne 1998

机译：第一部分：环状DNA作为可转换的DNA结合剂。第二部分高度选择性和灵敏的寡核苷酸探针
6. Selective Lighting Up of Epiberberine Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of Human Telomeric DNA G-Quadruplex Multimer [O] . Lihua Zhang, Hua Liu, Yong Shao, -1

机译：人端粒DNA G-四链体多聚体的荧光团转换适体和化学计量学靶向选择性点亮表皮小ber碱生物碱荧光。
7. Sequential double second-order nonlinear optical switch by an acido-triggered photochromic cyclometallated platinum(ii) complex. [O] . Boixel, Julien, Guerchais, Véronique, Le Bozec, Hubert, 2015

机译：由酸触发的光致变色环金属化铂（ii）配合物形成的顺序双二阶非线性光学开关。

A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

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