Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria

Marine J. Minvielle; Kristen Eguren; Christian Melander

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Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria

机译：吲哚信号的高活性调节剂可改变革兰氏阴性和革兰氏阳性细菌的致病性。

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Indole is a universal signal that regulates various bacterial behaviors, such as biofilm formation and antibiotic resistance. To generate mechanistic probes of indole signaling and control indole-mediated pathogenic phenotypes in both Gram-positive and Gram-negative bacteria, we have investigated the use of desformylflustrabromine (dFBr) derivatives to generate highly active indole mimetics. We have developed non-microbicidal dFBr derivatives that are 27–2000 times more active than indole in modulating biofilm formation, motility, acid resistance, and antibiotic resistance. The activity of these analogues parallels indole, because they are dependent on temperature, the enzyme tryptophanase TnaA, and the transcriptional regulator SdiA. This investigation demonstrates that molecules based on the dFBr scaffold can alter pathogenic behaviors by mimicking indole-signaling pathways.

机译：吲哚是调节各种细菌行为（例如生物膜形成和抗生素抗性）的通用信号。要生成革兰氏阳性和革兰氏阴性细菌中吲哚信号传导和控制吲哚介导的致病表型的机制探针，我们研究了去甲酰基氟乙溴（dFBr）衍生物用于产生高活性吲哚模拟物的方法。我们已经开发出非杀菌性的dFBr衍生物，在调节生物膜形成，运动性，耐酸性和抗生素抗性方面，其活性比吲哚高27-2000倍。这些类似物的活性与吲哚类似，因为它们取决于温度，色氨酸酶TnaA和转录调节子SdiA。这项研究表明，基于dFBr支架的分子可以通过模仿吲哚信号通路来改变致病行为。

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《Chemistry: A European journal》 |2013年第51期|共8页
作者
Marine J. Minvielle; Kristen Eguren; Christian Melander;
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desformylflustrabromine; mechanistic probes; natural products; phenotype control; structure–activity relationships;

机译：地甲酰氟溴溴;机械探针;天然产物;表型控制;结构-活性关系;

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1. Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria [J] . Marine J. Minvielle, Kristen Eguren, Christian Melander Chemistry: A European journal . 2013,第51期

机译：吲哚信号的高活性调节剂可改变革兰氏阴性和革兰氏阳性细菌的致病性。
2. Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria [J] . Marine J. Minvielle, Kristen Eguren, Christian Melander Chemistry: A European journal . 2013,第51期

机译：吲哚信号的高活性调节剂可改变革兰氏阴性和革兰氏阳性细菌的致病性。
3. Altered virulence of non-indole-producing pathogenic bacteria by indole signaling [J] . Paramaporn Rattanaphan, Thunchanok Yaikhan, Pawina Rachniyom, Sonklanakarin Journal of Science and Technology . 2020,第3期

机译：通过吲哚信号传导改变了非吲哚的致病细菌的毒力
4. Antibacterial Activities of β-Glucan (Laminaran) against Gram-Negative and Gram-Positive Bacteria [C] . A. Chamidah, Hardoko, A. A. Prihanto International Conference on Global Resource Conservation . 2017

机译：β-葡聚糖（Laminaran）对革兰阴性和革兰氏阳性细菌的抗菌活性
5. Adaptation of Gram-Negative and Gram-Positive Bacteria to a Newly Formulated Hand Sanitizer [D] . Al-Najjar, Eman Ahmad Jaber. 2021

机译：将革兰阴性和革兰氏阳性细菌的适应新配制的洗手液
6. Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria [O] . Marine J. Minvielle, Kristen Eguren, Christian Melander -1

机译：吲哚信号的高活性调节剂可改变革兰氏阴性和革兰氏阳性细菌的致病性。
7. Malaysian Isolates of Lactic Acid Bacteria with Antibacterial Activity against Gram-Positive and Gram-Negative Pathogenic Bacteria [O] . Mohamed Mustafa Aween, Mohamed Muftah Ahmed Imdakim, belal J muhialdin, 2012

机译：马来西亚乳酸菌对革兰氏阳性和革兰氏阴性致病菌具有抗菌活性

Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria

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