Toward the Total Synthesis of Haliclonin A: Construction of a Tricyclic Substructure

Shi-Peng Luo; Lian-Dong Guo; Long-Hui Gao; Shuang Li; Pei-Qiang Huang

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Toward the Total Synthesis of Haliclonin A: Construction of a Tricyclic Substructure

机译：进行Haliclonin A的全合成：三环亚结构的构建

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Haliclonin A (1) is a macrocyclic natural product isolated in 2009 from a marine sponge, Haliclona sp., collected from Korean waters.~([1]) The isolated compound was shown to be a mixture of two rotamers. The structure of the major rotamer was determined, only partially, on the basis of mass-spectrometric, spectroscopic, and chemical analyses. The absolute configuration of that portion was assigned as 1E,3S,4R,6S,11S. Preliminary bioassays showed that this compound exhibits moderate antibacterial activity against several microbial strains, and cytotoxicity against the K562 leukemia cell line with an IC_(50) value of 15.9 mgmL~(-1). However, to date, no synthetic study towards haliclonin A (1) has been reported.

机译：Haliclonin A（1）是2009年从韩国海域收集的海洋海绵Haliclona sp。中分离的大环天然产物。[（1））分离出的化合物显示为两种旋转异构体的混合物。根据质谱，光谱学和化学分析，仅部分确定了主要旋转异构体的结构。该部分的绝对配置分配为1E，3S，4R，6S，11S。初步的生物测定表明，该化合物对几种微生物菌株具有中等的抗菌活性，对K562白血病细胞系具有细胞毒性，IC_（50）值为15.9 mgmL〜（-1）。但是，迄今为止，尚无关于卤代茄宁A（1）的综合研究报告。

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《Chemistry: A European journal》 |2013年第1期|共5页
作者
Shi-Peng Luo; Lian-Dong Guo; Long-Hui Gao; Shuang Li; Pei-Qiang Huang;
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正文语种 eng
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Total Synthesis; Haliclonin; Substructure;

机译：全合成;Haliclonin;亚结构;

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1. Toward the Total Synthesis of Haliclonin A: Construction of a Tricyclic Substructure [J] . Shi-Peng Luo, Lian-Dong Guo, Long-Hui Gao, Chemistry: A European journal . 2013,第1期

机译：进行Haliclonin A的全合成：三环亚结构的构建
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3. Toward the racemic total synthesis of hederacines A and B: Construction of an advanced tricyclic intermediate [J] . Yamashita M., Yamashita T., Aoyagi S. Organic letters . 2011,第9期

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Toward the Total Synthesis of Haliclonin A: Construction of a Tricyclic Substructure

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