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首页> 外文期刊>Chemistry: A European journal >Tailored host-guest lipidic cubic phases: A protocell model exhibiting nucleic acid recognition
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Tailored host-guest lipidic cubic phases: A protocell model exhibiting nucleic acid recognition

机译：量身定制的来宾-客体脂质立方相：展示核酸识别的原始细胞模型

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摘要

A classical conundrum in origin-of-life studies relates to the nature of the first chemical system: was it a carrier of genetic information or a facilitator of cellular compartmentalization? Here we present a system composed of tailor-made nucleolipids and hydrated monoolein, which assemble at ambient temperatures to form host-guest lipidic cubic phase (LCP) materials that are stable in bulk water and can perform both functions. As such, they may represent a molecular model for a protocell in origin-of-life studies. Nucleolipids within the lipidic material sequester and bind selectively complementary oligonucleotide sequences from solution by virtue of base-pairing; noncomplementary sequences diffuse freely between the LCP material and the bulk aqueous environment. Sequence specific enrichment of nucleic acids within the LCP material demonstrates an effective mechanism for selection of genetic material in these cell-mimetic systems.
机译：生命起源研究中的一个经典难题与第一个化学系统的性质有关：它是遗传信息的载体还是细胞区室化的促进者？在这里，我们介绍了一个由量身定制的核苷酸和水合单油精组成的系统，它们在环境温度下组装形成主体客体脂质立方相（LCP）材料，该材料在散装水中稳定并且可以同时执行两种功能。这样，它们可以代表生命起源研究中的原始细胞的分子模型。脂质材料中的核脂质通过碱基配对螯合并与溶液中的选择性互补寡核苷酸序列结合;非互补序列在LCP材料和整体水性环境之间自由扩散。 LCP材料中核酸的序列特异性富集证明了在这些细胞模拟系统中选择遗传材料的有效机制。

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