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首页> 外文期刊>Chemistry: A European journal >Optical/magnetic multimodal bioprobes based on lanthanide-doped inorganic nanocrystals
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Optical/magnetic multimodal bioprobes based on lanthanide-doped inorganic nanocrystals

机译：基于镧系元素掺杂的无机纳米晶体的光学/磁性多峰生物探针

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摘要

Multimodal bioprobes, which integrate the advantages of different diagnostic modes into one single particle, can overcome the current limitations of sensitivity and resolution in medical assays and significantly improve the outcome of existing therapeutics. Lanthanide-doped inorganic multimodal bioprobes, which are emerging as a promising new class of optical/magnetic multimodal bioprobes, have been long sought-after and have recently attracted revived interest owing to their distinct optical and magnetic properties. In this concept article, we introduce the controlled synthesis of lanthanide-doped inorganic multimodal bioprobes, including core-shell structured and single-phase nanoparticles, and demonstrate different design strategies for achieving dual-modal functionalization of nanoprobes. In particular, we highlight the most recent advances in biodetection, bioimaging, targeted drug delivery, and therapy based on these nanoparticles. Must-see attractions: Lanthanide-doped inorganic nanoparticles have great potential as optical/magnetic multimodal bioprobes. Recent advances, from their design strategies to biomedical applications, are presented, with an emphasis on multimodal detection, in vitro and in vivo imaging, and medical diagnostics and therapeutics.
机译：将不同诊断模式的优势整合到一个颗粒中的多峰生物探针可以克服当前在医学分析中灵敏度和分离度的局限性，并显着改善现有疗法的疗效。掺杂镧系元素的无机多峰生物探针已成为一种有希望的新型光/磁多峰生物探针，由于其独特的光学和磁性性质，长期以来一直受到追捧，并且最近引起了人们的兴趣。在此概念文章中，我们介绍了镧系元素掺杂的无机多峰生物探针的受控合成，包括核-壳结构和单相纳米粒子，并展示了实现纳米探针双峰功能化的不同设计策略。特别是，我们重点介绍了基于这些纳米颗粒的生物检测，生物成像，靶向药物递送和治疗方面的最新进展。必看景点：掺杂镧系元素的无机纳米粒子作为光学/磁性多峰生物探针具有巨大潜力。介绍了从设计策略到生物医学应用的最新进展，重点是多模式检测，体外和体内成像以及医学诊断和治疗。

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