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首页> 外文期刊>Chemistry: A European journal >DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of NN-Heterocyclic-[Ru(η~6-arene)Cl_2] Drug Candidates
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DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of NN-Heterocyclic-[Ru(η~6-arene)Cl_2] Drug Candidates

机译：DMSO介导的配体解离：NN-杂环-[Ru（η〜6-arene）Cl_2]候选药物的生物活性的复兴。

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The swiftly progressing field of metal-based drug research has, in recent years, seen active interest in the development of non-platinated anticancer compounds. As an outcome of this shifting momentum, several new classes of metal complexes have been inducted into the library of potential alternatives.~([1]) With KP1019 and NAMI-A (both in phase II clinical trial) as two standout candidates, ruthenium (Ru) complexes continue to dominate the research in this direction.~([2]) One of the popularly studied class of compounds from the ruthenium family are the Ru~(II) organometallic complexes with a general formula [Ru(η~6-arene)(X)(Y)(Z)], in which the arene units and the ligands (X, Y and Z) resemble the seat and legs of the piano-stool, respectively (Figure l).~([3]) Also referred to as half sandwich "piano-stool" complexes, these have shown promising in vitro as well as in vivo anticancer activity.~([2-3])
机译：近年来，基于金属的药物研究迅速发展，人们对开发非镀铂抗癌化合物表现出了浓厚的兴趣。由于这种变化的势头，几种新类型的金属配合物已被引入到潜在的替代物库中。〜（[1]）以KP1019和NAMI-A（均在II期临床试验中）作为两个杰出的候选物，钌（Ru）络合物继续在这一方向上占据主导地位。〜（[2]）钌族化合物之一是被广泛研究的钌〜（II）通式为[Ru（η〜6）的有机金属络合物。 -芳烃] [X] [Y] [Z]]，其中芳烃单元和配体（X，Y和Z）分别类似于钢琴凳的座位和腿（图l）。〜（[3 ]）也称为半夹心“钢琴凳”复合物，它们在体外以及体内的抗癌活性均显示出良好的前景。[（2-3）]

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