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首页> 外文期刊>Chemistry: A European journal >Host–Guest Chemistry of Aromatic-Amide-Linked Bis- and Tris- Calix[4]pyrroles with Bis-Carboxylates and Citrate Anion
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Host–Guest Chemistry of Aromatic-Amide-Linked Bis- and Tris- Calix[4]pyrroles with Bis-Carboxylates and Citrate Anion

机译：芳酰胺键联的双-和三-杯[4]吡咯与双羧酸盐和柠檬酸根阴离子的客体化学

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摘要

A small library of polytopic receptors has been synthesized from meso-p- and meso-m-aminophenylcalix[4]- pyrroles and p- or m-phthaloyl or trimesic chloride. Selected bis-carboxylates and the citrate anion, which either exhibit altered distribution profiles in cancerous tissues in comparison with healthy tissues or are metabolites of carcinogenic substances (for example, trans,trans-muconic acid from benzene exposure in humans) were tested as ligands. Varied affinities and binding modes were observed as a function of the number of calix[4]pyrroles and the topology of amide units present in each of the polytopic receptors. The structures of the 1:1 complexes derived by molecular modeling are in excellent agreement with the results of ~1H NMR complexation studies.
机译：一个小型的多位受体文库是由间-对-和间-间-氨基苯基杯[4]-吡咯和对-或间-邻苯二甲酰或间苯三甲酰氯合成的。与健康组织相比，在癌组织中表现出改变的分布特征或是致癌物质的代谢产物（例如，人体内苯暴露产生的反式，反式粘康酸）作为配体，测试了选定的双羧酸盐和柠檬酸根阴离子。观察到各种亲和力和结合模式与杯[4]吡咯的数目和每个多位受体中酰胺单元拓扑的关系。通过分子模拟得出的1：1配合物的结构与〜1H NMR配合物研究的结果非常吻合。

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