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Unlocking the pH-Responsive Degradability of Fumaramic Acid Derivatives Using Photoisomerization

机译:使用光异构化解锁富马酸衍生物的pH响应降解性

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摘要

Fumaramic acid derivatives can be converted into their cis isomer maleamic acid derivatives under UV illumination, and these maleamic acid derivatives show pHresponsive degradability at acidic pH only after the preceding photoisomerization. The rate of the tandem photoisomerization- degradation of fumaramic acid derivatives can be finely controlled by changing the substituents on the double bond. Photoisomerization-based unlocking of the pH-responsive degradability of fumaramic acid derivatives has strong potential for the development of multisignal- responsive smart materials in biomedical applications.
机译:富马酰胺酸衍生物可以在紫外线照射下转化为顺式异构体马来酰胺酸衍生物,并且这些马来酰胺酸衍生物仅在之前的光异构化之后才在酸性pH下显示pH响应降解性。富马酰胺酸衍生物的串联光异构化降解速率可以通过改变双键上的取代基来精细控制。基于光异构化的富马酰胺酸衍生物的pH响应降解性解锁具有强大的潜力,可用于生物医学应用中多信号响应智能材料的开发。

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