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首页> 外文期刊>Chemistry: A European journal >Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles
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Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

机译：组织蛋白酶B诱导从肽封端的介孔二氧化硅纳米粒子的控制释放。

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摘要

New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate based on a cathepsin B target peptidic sequence were synthesized. Solids were designed to show "zero delivery" and to display cargo release in the presence of cathepsin B enzyme, which selectively hydrolyzed in vitro the capping peptide sequence. Controlled delivery in HeLa, MEFs WT, and MEFs lacking cathepsin B cell lines were also tested. Release of safranin O and doxorubicin in these cells took place when cathepsin B was active or present. Cells treated with S2-P showed a fall in cell viability due to nanoparticles internalization, cathepsin B hydrolysis of the capping peptide, and cytotoxic agent delivery, proving the possible use of these nanodevices as new therapeutic tools for cancer treatment.
机译：描述了在组织蛋白酶B表达细胞内用于细胞内受控货物释放的新的带帽二氧化硅介孔纳米颗粒。合成了装载有番红素O（S1-P）或阿霉素（S2-P）的纳米介孔MCM-41载体，该分子含有基于组织蛋白酶B靶肽序列的分子门。设计固体以显示“零递送”并在组织蛋白酶B酶存在下显示货物释放，所述组织蛋白酶B酶在体外选择性水解了封端肽序列。还测试了在HeLa，MEF WT和缺少组织蛋白酶B细胞系的MEF中的受控递送。当组织蛋白酶B活跃或存在时，番红花O和阿霉素在这些细胞中的释放。用S2-P处理的细胞由于纳米粒子内在化，组织肽B水解封端肽以及细胞毒性剂的递送而显示出细胞活力的下降，证明了将这些纳米装置用作癌症治疗的新治疗工具的可能性。

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