NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor

Christoph K. Winkler; Dorina Clay; Marcello Entner; Markus Plank; Kurt Faber

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NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor

机译：人工共底物作为氢供体，通过烯还原酶催化NAD（P）H独立的不对称C = C键还原

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摘要

To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C=C bonds, four types of hydrogen donor, encompassing more than 50 candidates, were investigated. Six highly potent, cheap, and commercially available co-substrates were identified that (under the optimized conditions) resulted in conversions and enantioselectivities comparable with, or even superior to, those obtained with traditional two-enzyme nicotinamide adenine dinucleotide phosphate (NAD(P)H)-recycling systems.

机译：为了开发不依赖烟酰胺的单一黄素酶系统以实现C = C键的不对称生物还原，研究了四种类型的氢供体，其中包括50多种候选物。鉴定出六种高效，廉价且可商购的共底物（在优化条件下），其转化和对映选择性可与甚至优于传统的两酶烟酰胺腺嘌呤二核苷酸磷酸酯（NAD（P））相比。 H）-回收系统。

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《Chemistry: A European journal》 |2014年第5期|共7页
作者
Christoph K. Winkler; Dorina Clay; Marcello Entner; Markus Plank; Kurt Faber;
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正文语种 eng
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alkene reduction; artificial biocatalysis; ene reductases; enzyme catalysis; hydrogen donors;

机译：烯烃还原人工生物催化烯还原酶酶催化氢供体;

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1. NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor [J] . Christoph K. Winkler, Dorina Clay, Marcello Entner, Chemistry: A European journal . 2014,第5期

机译：人工共底物作为氢供体，通过烯还原酶催化NAD（P）H独立的不对称C = C键还原
2. Enantioselective Reductive Cyclization of 1,6-Enynes via Rhodium-Catalyzed Asymmetric Hydrogenation:C-C Bond Formation Precedes Hydrogen Activation [J] . Hye-Young Jang, Freddie W.Hughes, Hegui Gong, Journal of the American Chemical Society . 2005,第17期

机译：通过铑催化的不对称加氢的1,6-烯炔的对映选择性还原环化：C-C键形成先于氢活化
3. Asymmetric reduction of α-keto esters with Thermus thermophilus NADH-dependent carbonyl reductase using glucose dehydrogenase and alcohol dehydrogenase for cofactor regeneration [J] . Pennacchio A., Giordano A., Rossi M., European journal of organic chemistry . 2011,第23期

机译：使用嗜热栖热菌NADH依赖性羰基还原酶不对称还原α-酮酯，使用葡萄糖脱氢酶和乙醇脱氢酶进行辅因子再生
4. ENGINEERING THE ENANTIOSELECTIVE REDUCTION OF CITRAL ISOMERS IN NCR ENE REDUCTASE [C] . Nico Kress, Johanna Rapp, Bernhard Hauer Enzyme Engineering Conference . 2018

机译：NCR Ene还原酶中携带类菌体异构体的映射减少
5. Highly stereoselective carbon-carbon bond-forming reactions: Asymmetric catalysis promoted by small-molecule hydrogen bond donors and cobalt -salen complexes [D] . McGilvra, Jeff D. 2007

机译：高度立体选择性的碳-碳键形成反应：小分子氢键供体和钴-salen配合物促进不对称催化
6. NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor [O] . Christoph K Winkler, Dorina Clay, Marcello Entner, -1

机译：人工共底物作为氢供体烯还原酶催化NAD（P）H独立的不对称C = C键还原
7. NAD(P)H-Independent Asymmetric CC Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor [O] . Christoph K. Winkler, Dorina Clay, Marcello Entner, 2013

机译：NAD（P）通过使用人工共衬片作为氢气供体，通过烯库催化的H-独立的不对称C 1C键减少

NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor

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