Stereoselective Total Synthesis and Structural Elucidation of (-)-Indoxamycins A-F

He Chi; Zhu Chenlong; Wang Bingnan; Ding Hanfeng

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Stereoselective Total Synthesis and Structural Elucidation of (-)-Indoxamycins A-F

机译：（-）-吲哚霉素A-F的立体选择性全合成和结构解析

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In this study, a concise and stereoselective approach for the divergent total synthesis of (-)-indoxamycins A-F is described. The key steps of the strategy include an Ireland-Claisen rearrangement, an enantioselective 1,6-enyne reductive cyclization, and a tandem 1,2-addition/oxa-Michael/methylenation reaction. The relative and absolute configuration of these natural products has been unambiguously elucidated, and their cytotoxic activities against HT-29 and A-549 tumor cell lines are also reported.

机译：在这项研究中，简明和立体选择性的方法描述了（-）-茚虫霉素A-F的不同总合成。该策略的关键步骤包括爱尔兰-克莱森重排，对映选择性1,6-烯炔还原环化和串联1,2-加成/氧杂-迈克尔/甲基化反应。已经明确阐明了这些天然产物的相对和绝对构型，并且还报道了它们对HT-29和A-549肿瘤细胞系的细胞毒活性。

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《Chemistry: A European journal》 |2014年第46期|共8页
作者
He Chi; Zhu Chenlong; Wang Bingnan; Ding Hanfeng;
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正文语种 eng
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biological evaluation; enyne cyclization; structure elucidation; tandem reaction; total synthesis;

机译：生物学评价烯炔环化结构阐明串联反应全合成;

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1. Stereoselective Total Synthesis and Structural Elucidation of (-)-Indoxamycins A-F [J] . He Chi, Zhu Chenlong, Wang Bingnan, Chemistry: A European journal . 2014,第46期

机译：（-）-吲哚霉素A-F的立体选择性全合成和结构解析
2. Stereoselective Total Synthesis and Structural Elucidation of (-)-Indoxamycins A-F [J] . He Chi, Zhu Chenlong, Wang Bingnan, Chemistry: A European journal . 2014,第46期

机译：（-）-吲哚霉素A-F的立体选择性全合成和结构解析
3. Stereoselective Synthesis of Dihydropyrone-Containing Marine Natural Products.Total Synthesis and Structural Elucidation of (-)-Membrenone-C [J] . Michael V.Perkins, Rebecca A.Sampson Organic letters . 2001,第1期

机译：含二氢吡喃酮的海洋天然产物的立体选择性合成。（-）-Membrenone-C的全合成和结构解析
4. Stereoselective synthesis of 2,2-substituted chromans: Towards the total synthesis of natural products. [C] . Gloria Hernandez-Torres, Mercedes Lecea, Antonio Urbano European Symposium on Organic Chemistry . 2009

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Stereoselective Total Synthesis and Structural Elucidation of (-)-Indoxamycins A-F

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