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首页> 外文期刊>Chemistry: A European journal >DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET–Optical Imaging**
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DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET–Optical Imaging**

机译：DMAP-BODIPY炔烃：标记双峰PET-光学成像生物分子的便捷工具**

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摘要

Several new boron dipyrromethene/N,N-dimethylaminopyridine (BODIPY-DMAP) assemblies were synthesized as precursors for bimodal imaging probes (optical imaging, OI/positron emission tomography, PET). The photophysical properties of the new compounds were also studied. The first proof-of-concept was obtained with the preparation of several new BODIPY-labeled bombesins and evaluation of the affinity for bombesin receptors by using a competition binding assay. Fluorination reactions were investigated on DMAP-BODIPY precursors as well as on DMAP-BODIPY-labeled bombesins. Chemical modifications on the BODIPY core were also performed to obtain luminescent dyes emitting in the therapeutic window (650–900 nm), suitable for in vivo imaging, making these compounds promising precursors for PET/optical dual-modality imaging agents.
机译：合成了几种新的硼二吡咯亚甲基/ N，N-二甲基氨基吡啶（BODIPY-DMAP）组件，作为双峰成像探针（光学成像，OI /正电子发射断层扫描，PET）的前体。还研究了新化合物的光物理性质。第一个概念证明是通过制备几种新的BODIPY标记的蛙皮素并通过竞争结合分析评估对蛙皮素受体的亲和力而获得的。对DMAP-BODIPY前体以及DMAP-BODIPY标记的蛙皮素进行了氟化反应。还对BODIPY核心进行了化学修饰，以获得在治疗窗口（650-900 nm）内发射的发光染料，适合体内成像，使这些化合物有望成为PET /光学双峰成像剂的前体。

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