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首页> 外文期刊>Chemistry: A European journal >The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases
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The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases

机译：过氧自由基，强大的有害试剂的作用解释了为什么胆固醇和饱和脂肪酸都不会引起动脉粥样硬化和与年龄有关的疾病

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摘要

Cells respond to alterations in their membrane structure by activating hydrolytic enzymes. Thus, polyunsaturated fatty acids (PUFAs) are liberated. Free PUFAs react with molecular oxygen to give lipid hydroperoxide molecules (LOOHs). In case of severe cell injury, this physiological reaction switches to the generation of lipid peroxide radicals (LOO.). These radicals can attack nearly all biomolecules such as lipids, carbohydrates, proteins, nucleic acids and enzymes, impairing their biological functions. Identical cell responses are triggered by manipulation of food, for example, heating/grilling and particularly homogenization, representing cell injury. Cholesterol as well as diets rich in saturated fat have been postulated to accelerate the risk of atherosclerosis while food rich in unsaturated fatty acids has been claimed to lower this risk. However, the fact is that LOO. radicals generated from PUFAs can oxidize cholesterol to toxic cholesterol oxides, simulating a reduction in cholesterol level. In this review it is shown how active LOO. radicals interact with biomolecules at a speed transcending usual molecule-molecule reactions by several orders of magnitude. Here, it is explained how functional groups are fundamentally transformed by an attack of LOO. with an obliteration of essential biomolecules leading to pathological conditions. A serious reconsideration of the health and diet guidelines is required.
机译：细胞通过激活水解酶来响应其膜结构的变化。因此，释放出多不饱和脂肪酸（PUFA）。游离的PUFA与分子氧反应生成脂质氢过氧化物分子（LOOH）。在严重细胞损伤的情况下，这种生理反应切换为脂质过氧化物自由基（LOO。）的产生。这些自由基可以攻击几乎所有生物分子，例如脂质，碳水化合物，蛋白质，核酸和酶，从而损害其生物学功能。通过处理食物（例如加热/烧烤，尤其是均质化）触发相同的细胞反应，这代表了细胞的损伤。胆固醇和富含饱和脂肪的饮食被认为可加速动脉粥样硬化的风险，而富含不饱和脂肪酸的食物则被认为可降低这种风险。但是，事实是LOO。 PUFA产生的自由基可将胆固醇氧化为有毒的胆固醇氧化物，从而模拟胆固醇水平的降低。在这篇评论中，它显示了活跃的LOO。自由基以比普通分子-分子反应高几个数量级的速度与生物分子相互作用。在这里，说明了如何通过LOO攻击从根本上转变功能组。消除导致病理状况的必需生物分子。需要认真考虑健康和饮食准则。

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