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首页> 外文期刊>Chemistry: A European journal >Divalent Transition-Metal-Ion Stress Induces Prodigiosin Biosynthesis in Streptomyces coelicolor M145: Formation of Coeligiosins
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Divalent Transition-Metal-Ion Stress Induces Prodigiosin Biosynthesis in Streptomyces coelicolor M145: Formation of Coeligiosins

机译：二价过渡金属离子应力诱导链霉菌Coelicolor M145中的prodigiosin生物合成：Coeligiosins的形成。

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摘要

The bacterium Streptomyces coelicolor M145 reacts to transition-metal-ion stress with myriad growth responses, leading to different phenotypes. In particular, in the presence of Co2+ ions (0.7mM) S. coelicolor consistently produced a red phenotype. This phenotype, when compared to the wild type, differed strongly in its production of volatile compounds as well as high molecular weight secondary metabolites. LC-MS analysis revealed that in the red phenotype the production of the prodigiosins, undecylprodigiosin and streptorubinB, was strongly induced and, in addition, several intense signals appeared in the LC-MS chromatogram. Using LC-MS/MS and NMR spectroscopy, two new prodigiosin derivatives were identified, that is, coeligiosinA and B, which contained an additional undecylpyrrolyl side chain attached to the central carbon of the tripyrrole ring system of undecylprodigiosin or streptorubinB. This example demonstrates that environmental factors such as heavy metal ion stress can not only induce the production of otherwise not observed metabolites from so called sleeping genes but alter the products from well-studied biosynthetic pathways.
机译：细菌天蓝色链霉菌M145对过渡金属离子胁迫产生多种生长反应，导致不同的表型。特别是，在存在Co2 +离子（0.7mM）的情况下，天蓝色链霉菌始终产生红色表型。与野生型相比，该表型在挥发性化合物以及高分子量次生代谢产物的生产上有很大差异。 LC-MS分析显示，在红色表型中，强烈诱导了原黄酮素，十一烷基原黄酮素和链霉菌素B的产生，此外，LC-MS色谱图中还出现了一些强烈的信号。使用LC-MS / MS和NMR光谱法，鉴定出两个新的prodigiosin衍生物，即腔肠素A和B，其中包含一个附加的十一烷基吡咯烷基侧链，该附加的十一烷基吡咯烷基侧链连接到十一烷基prodigiosin或streptorubinB的三吡咯环系统的中央碳上。这个例子表明，诸如重金属离子胁迫之类的环境因素不仅可以诱导所谓睡眠基因产生其他未观察到的代谢产物，而且可以改变经过深入研究的生物合成途径的产物。

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