• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Construction of the Isocopalane Skeleton: Application of a Desulfinylative 1,7-Hydrogen Atom Transfer Strategy
【24h】

Construction of the Isocopalane Skeleton: Application of a Desulfinylative 1,7-Hydrogen Atom Transfer Strategy

机译：异铜烷骨架的构建：脱硫酰化的1,7-氢原子转移策略的应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two attractive chirons, aldehyde 6 and chloride 7, exhibiting functionalized ent-spongiane-type tricyclic skeletons (ABC ring system), have been constructed and their absolute configurations have been studied by NMR spectroscopy and confirmed by single-crystal X-ray diffraction. Both of these chirons are derived from commercially available andrographolide in good yield. Aldehyde 6 is obtained through a novel K2S2O8-catalyzed aquatic ring-closing reaction of allylic sodium sulfonate and intramolecular 1,7-hydrogen atom transfer process. Further mechanistic investigations demonstrate that the 1,7-hydrogen atom transfer is a free-radical process, whereby hydrogen migrates from C18 to C17, as evidenced by double-18- deuterium-labeled isotope experiments. Prospective applications of these two chiral sources are also discussed.
机译：构造了两个有吸引力的丁二醛，分别是醛化6和氯化物7，它们具有官能化的对偶-海绵型三环骨架（ABC环系统），并且它们的绝对构型已通过NMR光谱研究，并通过单晶X射线衍射得以证实。这两种Chiron均以良好的产率衍生自市售穿心莲内酯。通过新型的K2S2O8催化的烯丙基磺酸钠的水生闭环反应和分子内1,7-氢原子转移过程获得醛6。进一步的机械研究表明，1,7-氢原子转移是一个自由基过程，氢由此从C18迁移到C17，双18氘标记的同位素实验证明了这一点。还讨论了这两种手性来源的预期应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号