Asymmetric Suzuki-Miyaura Cross-Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands

Ma Yan-Na; Yang Shang-Dong

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Asymmetric Suzuki-Miyaura Cross-Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands

机译：不对称的Suzuki-Miyaura交叉偶联用于合成潜在的单膦配体的手性联芳基化合物

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Efficient asymmetric Suzuki-Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to > 95: 5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.

机译：高效的不对称Suzuki-Miyaura偶联反应已首次用于合成具有次膦酸酯基团的手性联芳基化合物作为手性助剂。由此以优异的产率和良好的非对映选择性（高达＞ 95∶5 d.r.）合成了一系列官能化的手性联芳基，并且通过进一步的官能化获得了轴向手性的单磷配体。

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《Chemistry: A European journal》 |2015年第18期|共5页
作者
Ma Yan-Na; Yang Shang-Dong;
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正文语种 eng
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关键词
asymmetric synthesis; biaryl compounds; cross-coupling; ligand design; phosphanes;

机译：不对称合成;芳基化合物;交叉偶联;配体设计;膦;

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专利

1. Asymmetric Suzuki-Miyaura Cross-Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands [J] . Ma Yan-Na, Yang Shang-Dong Chemistry: A European journal . 2015,第18期

机译：不对称的Suzuki-Miyaura交叉偶联用于合成潜在的单膦配体的手性联芳基化合物
2. Enantioselective synthesis of biaryl compounds via Suzuki-Miyaura cross-coupling using a palladium complex of 7′-butoxy-7- (diphenylphosphino)-8,8′-biquinolyl: Investigation of a new chiral ligand architecture [J] . WuZ., WangC., ZakharovL.N., Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2014,第5期

机译：使用7'-丁氧基-7-（二苯基膦基）-8,8'-联喹啉钯的钯配合物，通过Suzuki-Miyaura交叉偶联对联芳基化合物的对映选择性合成：新手性配体结构的研究
3. Palladium catalyzed asymmetric Suzuki-Miyaura coupling reactions to axially chiral biaryl compounds: Chiral ligands and recent advances [J] . Zhang Dao, Wang Quanrui Coordination chemistry reviews . 2015,第mara期

机译：钯催化轴向手性联芳基化合物的不对称Suzuki-Miyaura偶联反应：手性配体和最新进展
4. Asymmetric Synthesis of Axially Chiral Biaryls:Inversion of Planar Chirality vs.Axial Isomerization [C] . Ken Kamikawa, Tomohiro Sakamoto, Yoshie Tanaka, Symposium on Organometallic Chemistry . 2003

机译：轴向手性的不对称合成：平面手平性的反演vs.Axial异构化
5. I. Heterogeneous cross-coupling reactions catalyzed by nickel-in-charcoal and copper-in-charcoal. II. Asymmetric 1,2/1,4-reductions catalyzed by copper hydride. III. Atropselective synthesis of the biaryl A-B ring system of vancomycin utilizing an internally tethered, nonracemic ligand. [D] . Lee, Ching-Tien. 2009

机译：I.炭中镍和炭中铜催化的非均相交叉偶联反应。二。氢化铜催化的不对称1,2 / 1,4-还原反应。三，利用内部束缚的非外消旋配体进行万古霉素联芳基A-B环系统的选择性催化合成。
6. Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis [O] . Nitinchandra Dahyabhai Patel, Joshua D. Sieber, Sergei Tcyrulnikov, -1

机译：Pd催化的不对称Suzuki-Miyaura和Neshishi交叉偶联反应的计算辅助机理研究与开发用于四邻位取代联芳基的合成
7. Back Cover: Asymmetric Suzuki-Miyaura Cross-Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands (Chem. Eur. J. 18/2015) [O] . Yan-Na Ma, Shang-Dong Yang 2015

机译：封底：不对称铃木宫颈交叉耦合，用于合成手性前列化合物作为潜在单膦配体（Chem.EUR。J. 18/2015）

Asymmetric Suzuki-Miyaura Cross-Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands

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