Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons

Li Dan; Yang Dongxu; Wang Linqing; Liu Xihong; Jiang Xianxing; Wang Rui

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Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons

机译：Mg-II催化内消旋氮丙啶与羟胺的不对称反应：新型手性1,2-二胺骨架的合成

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A Mg-II-catalyzed desymmetrization reaction of meso-aziridines with hydroxylamines has been disclosed for the first time. A series of novel chiral 1,2-diamine skeletons were obtained in good yields and enantioselectivities. The reaction employed magnesium catalysis generated in situ from a simple oxazoline-OH chiral ligand. Obviously, the diverse structures of the obtained chiral 1,2-diamine compounds could allow them to be potential chiral ligands in future catalytic asymmetric synthesis studies.

机译：首次公开了Mg-II催化的内消旋氮丙啶与羟胺的脱对称反应。以良好的产率和对映选择性获得了一系列新颖的手性1,2-二胺骨架。该反应采用由简单的恶唑啉-OH手性配体原位产生的镁催化。显然，获得的手性1,2-二胺化合物的不同结构可能使它们成为未来催化不对称合成研究中潜在的手性配体。

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《Chemistry: A European journal》 |2016年第48期|共4页
作者
Li Dan; Yang Dongxu; Wang Linqing; Liu Xihong; Jiang Xianxing; Wang Rui;
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正文语种 eng
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关键词
asymmetric synthesis; diamines; hydroxylamine; magnesium; oxazoline;

机译：不对称合成;二胺;羟胺;镁;恶唑啉;

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1. Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons [J] . Li Dan, Yang Dongxu, Wang Linqing, Chemistry: A European journal . 2016,第48期

机译：Mg-II催化内消旋氮丙啶与羟胺的不对称反应：新型手性1,2-二胺骨架的合成
2. Useful Applications of Enantioselective (4+2)-Cycloaddition Reactions to the Synthesis of Chiral 1,2-Amino Alcohols, 1,2-Diamines, and beta-Amino Acids [J] . Reddy Karla Mahender, Thirupathi Barla, Corey E. J. Organic letters . 2017,第18期

机译：对映选择性（4 + 2）-cycloaddition反应对合成手性1,2-氨基醇，1,2-二胺和β-氨基酸的有用应用
3. Chiral Bronsted Acid-Promoted Enantioselective Desymmetrization in an Intramolecular Schmidt Reaction of Symmetric Azido 1,3-Hexanediones: Asymmetric Synthesis of Azaquaternary Pyrroloazepine Skeletons [J] . Ming Yang, Yu-Ming Zhao, Shu-Yu Zhang, Chemistry, an Asian journal . 2011,第6期

机译：对称叠氮基1,3-己二酮的分子内Schmidt反应中的手性布朗斯台德酸促进的对映选择性脱对称：氮杂季铵吡咯并氮杂骨架的不对称合成。
4. Synthesis of Polymer-supported Chiral 1,2-Diamine by Polycondensation and Its Application to Asymmetric Hydrogenation [C] . Naoki Haraguchi, Nilesh Anand Prasad, Takao Uchiyama, World Multiconference on Systemics, Cybernetics and Informatics . 2006

机译：通过缩聚合成聚合物支持的手性1,2-二胺及其在不对称氢化中的应用
5. Synthesis of (1R,2R)-N1,N2-Dibenzylcyclohexane-1,2-diamine as an Auxiliary for a Stereoselective 1,4 Conjugate Addition Reaction; Construction of Polymer Bound (1R,2R)- 1,2-Cyclohexanediamine to evaluate the Solid-Phase Counterpart, and Methodology Development for Synthesis of Functionalized Oligothiophenes. [D] . Poorjahanshah, Homer. 2016

机译：（1R，2R）-N1，N2-二苄基环己烷-1，2-二胺作为立体选择性1，4共轭加成反应的助剂的合成；聚合物结合的（1R，2R）-1,2-环己二胺的构建以评价固相配对物，以及功能化寡聚噻吩的合成方法开发。
6. Chiral Phosphoric Acid-Catalyzed Desymmetrization of meso-Aziridines with Functionalized Mercaptans [O] . Shawn E. Larson, Juan C. Baso, Guilong Li, -1

机译：与功能化的硫醇细观彭孝军手性磷酸催化Desymmetrization
7. Expedient Synthesis of Chiral 1,2- and 1,4-Diamines: Protecting Group Dependent Regioselectivity in Direct Organocatalytic Asymmetric Mannich Reactions. [O] . Naidu S. Chowdari, Moballigh Ahmad, Klaus Albertshofer, 2006

机译：有利的合成手性1,2-和1,4-二胺：保护基团依赖性区域选择性直接有机催化不对称曼尼奇反应。
8. Synthesis of Methylhydrazine and 1,1-Dimethylhydrazine by the Reactions of Hydroxylamine-O-Sulfonic Acid with Methyl- and Dimethylamine [R] . Sisler, H. H., Mathur, M. A., Jain, S. R. 1980

机译：羟胺-O-磺酸与甲基和二甲胺反应合成甲基肼和1,1-二甲基肼

Mg-II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons

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