Production of Pure Aqueous C-13-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization

Kovtunov Kirill V.; Barskiy Danila A.; Shchepin Roman V.; Salnikov Oleg G.; Prosvirin Igor P.; Bukhtiyarov Andrey V.; Kovtunova Larisa M.; Bukhtiyarov Valerii I.; Koptyug Igor V.; Chekmenev Eduard Y.

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Production of Pure Aqueous C-13-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization

机译：非均相对氢诱导极化法制备纯净的C-13超极化乙酸盐

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A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce C-13-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO2 catalyst with a metal loading of 23.2wt% produced strongly hyperpolarized C-13-enriched ethyl acetate-1-C-13 detected at 9.4 T. An approximately 14-fold C-13 signal enhancement was detected using circa 50% parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to C-13 nuclei. This first observation of C-13 PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.

机译：设计，表征和测试了负载型金属催化剂，用于乙酸乙烯酯与对氢的水相非均相加氢反应，以生产C-13超极化乙酸乙酯，用于潜在的生物医学应用。金属负载量为23.2wt％的Rh / TiO2催化剂在9.4 T下产生了强烈超极化的富含C-13的乙酸乙酯-1-C-13。使用约50％的C-13信号增强了约14倍从氢衍生的质子到C-13原子核的磁场循环极化转移之前和之后的极化损失之前和之后的弛豫损失，都没有考虑到这种情况。在含水介质中负载金属催化剂上对C-13 PHIP超极化产物的首次观察，为无毒超极化造影剂的无催化剂水溶液的生产开辟了新的可能性，该无毒超极化造影剂适用于各种可通过对氢诱导的极化的生物分子。侧臂氢化（PHIP-SAH）方法。

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《Chemistry: A European journal》 |2016年第46期|共4页
作者
Kovtunov Kirill V.; Barskiy Danila A.; Shchepin Roman V.; Salnikov Oleg G.; Prosvirin Igor P.; Bukhtiyarov Andrey V.; Kovtunova Larisa M.; Bukhtiyarov Valerii I.; Koptyug Igor V.; Chekmenev Eduard Y.;
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正文语种 eng
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C-13 NMR; hyperpolarization; parahydrogen; PHIP; polarization transfer;

机译：C-13 NMR;超极化;对氢;PHIP;极化转移;

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1. Production of Pure Aqueous C-13-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization [J] . Kovtunov Kirill V., Barskiy Danila A., Shchepin Roman V., Chemistry: A European journal . 2016,第46期

机译：非均相对氢诱导极化法制备纯净的C-13超极化乙酸盐
2. Toward production of pure C-13 hyperpolarized metabolites using heterogeneous parahydrogen-induced polarization of ethyl[1-C-13]acetate [J] . Kovtunov K. V., Barskiy D. A., Salnikov O. G., RSC Advances . 2016,第74期

机译：利用异质戊二原诱导的乙酸乙酯偏振产生纯C-13超极化代谢物的纯C-13超极化代谢物[1-C-13]乙酸酯
3. Toward production of pure 13C hyperpolarized metabolites using heterogeneous parahydrogen-induced polarization of ethyl[1-13C]acetate [J] . K. V. Kovtunov, D. A. Barskiy, O. G. Salnikov, RSC Advances . 2016,第74期

机译：利用乙酸乙酯的非均相戊二原诱导的乙酸乙酯偏振产生纯13C超极化代谢物的生产
4. Organometallic Approaches to Optimization of Rhodium Catalysts for Efficient Parahydrogen-Induced Polarization [C] . Yuki Naganawa, Marino Itoda, Hiroshi Nonaka 日本化学会春季年会講演予稿集 . 2018

机译：有机金属化方法优化铑催化剂，以高效戊二原诱导极化
5. Ester hydrolysis of cellulose acetate and cellulose acetate phthalate in aqueous suspension and solution, and solid state. [D] . Garcia, Thomas Patrick. 1989

机译：醋酸纤维素和醋酸纤维素邻苯二甲酸酯在水悬浮液和溶液中的酯水解，呈固态。
6. Production of Pure Aqueous 13C-Hyperpolarized Acetate Via Heterogeneous Parahydrogen-Induced Polarization [O] . Dr Kirill V. Kovtunov, Dr. Danila A. Barskiy, Dr. Roman V. Shchepin, -1

机译：通过非均相对氢诱导极化产生纯13C超极化乙酸水溶液
7. Production of Pure Aqueous 13 C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization [O] . Kirill V. Kovtunov, Danila A. Barskiy, Roman V. Shchepin, 2016

机译：通过非均相戊二糖诱导的极化生产纯33个C-超极化乙酸盐
8. The Dielectric Relaxation Spectra of Water, Ice, and Aqueous Solutions and Their Interpretation. Viii. Transfer of Protons Through 'Pure' Ice I(H) Single Crystals. I. Polarization Spectra of Ice I(H). Ii. Molecular Models for Polarization and Conduction. Iii. Extrinsic- Versus Intrinsic Polarization; Surface- Versus Volume Conduction [R] . von Hippel, A. R., Knoll, D. B., Maidique, M. A., 1970

机译：水，冰和水溶液的介电弛豫谱及其解释。八。通过'纯'冰I（H）单晶转移质子。 I.冰I（H）的偏振光谱。二。极化和传导的分子模型。三。外在与内在极化;表面与体积传导

Production of Pure Aqueous C-13-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization

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